Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. - Test2 - elhamkhani - TriplyDB

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.

http://www.wikidata.org/entity/Q30492111

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Hypoxia-based strategies for angiogenic induction: the dawn of a new era for ischemia therapy and tissue regeneration Hypoxia-inducible factors and the response to hypoxic stress Redox regulation of stem/progenitor cells and bone marrow niche Hypoxia-inducible factors in physiology and medicine Hypoxia-inducible factor 1 and cardiovascular disease Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition Enhanced angiogenesis in ischemic skeletal muscle after transplantation of cell sheets from baculovirus-transduced adipose-derived stromal cells expressing VEGF165 Pluronic L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia The bone-forming effects of HIF-1α-transduced BMSCs promote osseointegration with dental implant in canine mandible.Systemic preconditioning by a prolyl hydroxylase inhibitor promotes prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells.Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis.Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue.Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection.Constitutive HIF-1α expression blunts the beneficial effects of cardiosphere-derived cell therapy in the heart by altering paracrine factor balance.Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice.Hypoxia-inducible factor as an angiogenic master switch Hypoxia-inducible factors and the prevention of acute organ injury.Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells Akt/hypoxia-inducible factor-1α signaling deficiency compromises skin wound healing in a type 1 diabetes mouse model Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes Collaterals: Implications in cerebral ischemic diseases and therapeutic interventions Hypoxia-induced angiogenesis: good and evil Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment.Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor.Hypoxia-Inducible Factor-1: A Critical Player in the Survival Strategy of Stressed Cells.Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds.Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression From bench to bedside: review of gene and cell-based therapies and the slow advancement into phase 3 clinical trials, with a focus on Aastrom's Ixmyelocel-T.Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus.Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.Prolyl 4-hydroxylases, master regulators of the hypoxia response.Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization.Prolyl hydroxylase inhibitors act as agents to enhance the efficiency of cell therapy.

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Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.

http://www.wikidata.org/entity/Q30492111

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009年の論文

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2009年論文

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2009年論文

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2009年论文

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PNAS.0911921106

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Proceedings of the National Academy of Sciences of the United States of America

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Synergistic effect of HIF-1alp ...... mouse model of limb ischemia.

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Alexandra McMillan

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Andre Levchenko

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C Joanne Wang

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KangAe Lee

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Kshitiz Gupta

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Nupura Bhise

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Sergio Rey

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Shaoping Chen

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P2860

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Isolation of putative progenitor endothelial cells for angiogenesis

Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.

Flow-mediated endothelial mechanotransduction.

Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines.

Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies.

Hypoxia-responsive transcription factors.

Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells.

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20399-20404

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10.1073/PNAS.0911921106

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48

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106

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Gregg L. Semenza

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2009-11-30T00:00:00Z

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40042067

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19948968

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2787122

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