Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Item
http://www.wikidata.org/entity/Q28822022
Structural basis of PROTAC cooperative recognition for selective protein degradationStructure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin LigasesImpact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.Chemical Methods to Knock Down the Amyloid Proteins.Targeted protein knockdown using small molecule degraders.Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB.Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.STAT3 precedes HIF1α transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes.
P2860

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Item
http://www.wikidata.org/entity/Q28822022
description
2016 nî lūn-bûn
@nan
2016 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Potent and selective chemical ...... droxylation via VHL inhibition
@ast
Potent and selective chemical ...... droxylation via VHL inhibition
@en
type
label
Potent and selective chemical ...... droxylation via VHL inhibition
@ast
Potent and selective chemical ...... droxylation via VHL inhibition
@en
prefLabel
Potent and selective chemical ...... droxylation via VHL inhibition
@ast
Potent and selective chemical ...... droxylation via VHL inhibition
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P3181
P356
P407
P478
P50
P577
P6179
P698
P921
P932
P3181
P356
P1433
P1476
Potent and selective chemical ...... droxylation via VHL inhibition
@en
P2093
P2860
P2888
P304
P31
P3181
P356
P407
P478
P50
P577
P6179
P698
P921
P932