Proliferation control strategies to improve productivity and survival during CHO based production culture : A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell lines

Proliferation control strategies to improve productivity and survival during CHO based production culture : A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell lines

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http://www.wikidata.org/entity/Q30492978

Q30492978

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CO2 - Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes Genomics in mammalian cell culture bioprocessing Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures Differential protein expression following low temperature culture of suspension CHO-K1 cells Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment - comparative transcriptome analysis with CHO cDNA microarrays High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Cyclin and DNA distributed cell cycle model for GS-NS0 cells.Glycosylation and post-translational modification gene expression analysis by DNA microarrays for cultured mammalian cells.Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures Production of α2,6-sialylated IgG1 in CHO cells Metabolomics profiling of extracellular metabolites in CHO-K1 cells cultured in different types of growth media.Differential response in downstream processing of CHO cells grown under mild hypothermic conditions.pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.Cell line development for biomanufacturing processes: recent advances and an outlook.Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality.Application of a nonradioactive method of measuring protein synthesis in industrially relevant Chinese hamster ovary cells.Control of the timing and dosage of IGF-I delivery from encapsulated cells.Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α1-antitrypsin production at reduced pyruvate load.Extracellular purine and pyrimidine catabolism in cell culture.Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.Bovine viral diarrhea virus structural protein E2 as a complement regulatory protein.Verhulst and stochastic models for comparing mechanisms of MAb productivity in six CHO cell lines Murine norovirus replication induces G0/G1 cell cycle arrest in asynchronously growing cells.Revisiting Verhulst and Monod models: analysis of batch and fed-batch cultures.Enhanced production of recombinant rabies virus glycoprotein (rRVGP) by Drosophila melanogaster S2 cells through control of culture conditions.Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.A kinetic-metabolic model based on cell energetic state: study of CHO cell behavior under Na-butyrate stimulation.Sustaining an efficient and effective CHO cell line development platform by incorporation of 24-deep well plate screening and multivariate analysis.Behaviour and ultrastructure of human bone marrow-derived mesenchymal stem cells immobilised in alginate-poly-l-lysine-alginate microcapsules.A quantitative proteomic analysis of cellular responses to high glucose media in Chinese hamster ovary cells.Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro-bioreactor system.Comparative Proteomic Analysis of Three Chinese Hamster Ovary (CHO) Host Cells.Enhanced production of recombinant proteins by a small molecule protein synthesis enhancer in combination with an antioxidant in recombinant Chinese hamster ovary cells.The Saccharomyces cerevisiae pheromone-response is a metabolically active stationary phase for bio-production.Understanding the intracellular effects of yeast extract on the enhancement of Fc-fusion protein production in Chinese hamster ovary cell culture.Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype.Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture.High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells Engineering a mammalian super producer

P2860

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P2860

Proliferation control strategies to improve productivity and survival during CHO based production culture : A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell lines

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