Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.
about
Cortical dynein is critical for proper spindle positioning in human cellsMAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosisThe G protein α chaperone Ric-8 as a potential therapeutic targetActivators of G protein signaling exhibit broad functionality and define a distinct core signaling triadRGS14 at the interface of hippocampal signaling and synaptic plasticityHuman Nek7-interactor RGS2 is required for mitotic spindle organization.B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency.Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal deathResistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activityInscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisionsDNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiaeActivation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8ANCAM180 regulates Ric8A membrane localization and potentiates β-adrenergic responseNuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein functionChromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientationCortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphaseCell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.Ric-8: different cellular roles for a heterotrimeric G-protein GEF.Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progressionEvidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cellsThe novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.Canonical and noncanonical g-protein signaling helps coordinate actin dynamics to promote macrophage phagocytosis of zymosanSLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientationLoss of Gαi proteins impairs thymocyte development, disrupts T-cell trafficking, and leads to an expanded population of splenic CD4+PD-1+CXCR5+/- T-cellsImplications of non-canonical G-protein signaling for the immune systemThe nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.Asymmetric cell divisions promote Notch-dependent epidermal differentiation.A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cellsOverexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase.Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization.G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cellsExpression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis.Cell shape impacts on the positioning of the mitotic spindle with respect to the substratum.Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomesA novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning.Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis.Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation.Cell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase.
P2860
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P2860
Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.
@ast
Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.
@en
type
label
Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.
@ast
Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.
@en
prefLabel
Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.
@ast
Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.
@en
P2093
P2860
P356
P1476
Ric-8A and Gi alpha recruit LG ...... lp orient the mitotic spindle.
@en
P2093
Geoffrey E Woodard
Gregory G Tall
Hyeseon Cho
John H Kehrl
Ning-Na Huang
P2860
P304
P356
10.1128/MCB.00394-10
P407
P577
2010-05-17T00:00:00Z