Interaction between alk1 and blood flow in the development of arteriovenous malformations - Test2 - elhamkhani - TriplyDB

Interaction between alk1 and blood flow in the development of arteriovenous malformations

Interaction between alk1 and blood flow in the development of arteriovenous malformations

http://www.wikidata.org/entity/Q30498969

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BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia Targeting BMP signalling in cardiovascular disease and anaemia Animal Models in Studying Cerebral Arteriovenous Malformation Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations.Blood flow changes coincide with cellular rearrangements during blood vessel pruning in zebrafish embryos 3-OST-7 regulates BMP-dependent cardiac contraction Haemodynamics-driven developmental pruning of brain vasculature in zebrafish High resolution imaging of vascular function in zebrafish Critical transitions in early embryonic aortic arch patterning and hemodynamics The hemodynamically-regulated vascular microenvironment promotes migration of the steroidogenic tissue during its interaction with chromaffin cells in the zebrafish embryo Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2 'In parallel' interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate model Manipulation of zebrafish's orientation using artificial cilia in a microchannel with actively adaptive wall design ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.The zebrafish as a tool to identify novel therapies for human cardiovascular disease.Shear induced collateral artery growth modulated by endoglin but not by ALK1.The pathobiology of vascular malformations: insights from human and model organism genetics.Human brain arteriovenous malformations express lymphatic-associated genes.Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point.Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14 Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.Fluid flows and forces in development: functions, features and biophysical principles.Hemangiomas and vascular malformations: current theory and management.BMP9 regulates endoglin-dependent chemokine responses in endothelial cells.Reck enables cerebrovascular development by promoting canonical Wnt signaling.Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence Alk1 controls arterial endothelial cell migration in lumenized vessels Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia.Endothelial signaling and the molecular basis of arteriovenous malformation.Zebrafish models of cerebrovascular disease.Cerebrovascular disorders: molecular insights and therapeutic opportunities.Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease.Mechanotransduction in embryonic vascular development.Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy.Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects.VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning.

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P2860

Interaction between alk1 and blood flow in the development of arteriovenous malformations

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2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Interaction between alk1 and blood flow in the development of arteriovenous malformations

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Interaction between alk1 and blood flow in the development of arteriovenous malformations

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Interaction between alk1 and blood flow in the development of arteriovenous malformations

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Interaction between alk1 and blood flow in the development of arteriovenous malformations

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Interaction between alk1 and blood flow in the development of arteriovenous malformations

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Beth L Roman

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Chia-Yuan Chen

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Elizabeth R Rochon

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Kerem Pekkan

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Michael J Patrick

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Paola Corti

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Sarah Young

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P2860

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

Bone morphogenetic protein-9 is a circulating vascular quiescence factor

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

Stages of embryonic development of the zebrafish

Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1

Crystal structure of BMP-9 and functional interactions with pro-region and receptors

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor

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1573-1582

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10.1242/DEV.060467

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8

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138

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21389051

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arteriovenous malformation

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3062425

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