Interaction between alk1 and blood flow in the development of arteriovenous malformations
about
BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasiaTargeting BMP signalling in cardiovascular disease and anaemiaAnimal Models in Studying Cerebral Arteriovenous MalformationLine-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animalsContext-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations.Blood flow changes coincide with cellular rearrangements during blood vessel pruning in zebrafish embryos3-OST-7 regulates BMP-dependent cardiac contractionHaemodynamics-driven developmental pruning of brain vasculature in zebrafishHigh resolution imaging of vascular function in zebrafishCritical transitions in early embryonic aortic arch patterning and hemodynamicsThe hemodynamically-regulated vascular microenvironment promotes migration of the steroidogenic tissue during its interaction with chromaffin cells in the zebrafish embryoEnhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2'In parallel' interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flowDeletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate modelManipulation of zebrafish's orientation using artificial cilia in a microchannel with actively adaptive wall designALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.The zebrafish as a tool to identify novel therapies for human cardiovascular disease.Shear induced collateral artery growth modulated by endoglin but not by ALK1.The pathobiology of vascular malformations: insights from human and model organism genetics.Human brain arteriovenous malformations express lymphatic-associated genes.Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point.Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.Fluid flows and forces in development: functions, features and biophysical principles.Hemangiomas and vascular malformations: current theory and management.BMP9 regulates endoglin-dependent chemokine responses in endothelial cells.Reck enables cerebrovascular development by promoting canonical Wnt signaling.Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formationCirculating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescenceAlk1 controls arterial endothelial cell migration in lumenized vesselsDefective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia.Endothelial signaling and the molecular basis of arteriovenous malformation.Zebrafish models of cerebrovascular disease.Cerebrovascular disorders: molecular insights and therapeutic opportunities.Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease.Mechanotransduction in embryonic vascular development.Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy.Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects.VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning.
P2860
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P2860
Interaction between alk1 and blood flow in the development of arteriovenous malformations
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Interaction between alk1 and blood flow in the development of arteriovenous malformations
@ast
Interaction between alk1 and blood flow in the development of arteriovenous malformations
@en
type
label
Interaction between alk1 and blood flow in the development of arteriovenous malformations
@ast
Interaction between alk1 and blood flow in the development of arteriovenous malformations
@en
prefLabel
Interaction between alk1 and blood flow in the development of arteriovenous malformations
@ast
Interaction between alk1 and blood flow in the development of arteriovenous malformations
@en
P2093
P2860
P356
P1433
P1476
Interaction between alk1 and blood flow in the development of arteriovenous malformations
@en
P2093
Beth L Roman
Chia-Yuan Chen
Elizabeth R Rochon
Kerem Pekkan
Michael J Patrick
Paola Corti
Sarah Young
P2860
P304
P356
10.1242/DEV.060467
P407
P577
2011-03-09T00:00:00Z