High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing. - Test2 - elhamkhani - TriplyDB

High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing.

High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing.

http://www.wikidata.org/entity/Q30503321

about

Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans Structural basis for the recognition of diastereomeric 5',8-cyclo-2'-deoxypurine lesions by the human nucleotide excision repair system Generation of guanine-amino acid cross-links by a free radical combination mechanism Replication studies of carboxymethylated DNA lesions in human cells.Cytotoxic and mutagenic properties of regioisomeric O²-, N3- and O⁴-ethylthymidines in bacterial cells.Pyrosequencing: applicability for studying DNA damage-induced mutagenesis.Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.Transcriptional inhibition and mutagenesis induced by N-nitroso compound-derived carboxymethylated thymidine adducts in DNA.In vitro replication studies of carboxymethylated DNA lesions with Saccharomyces cerevisiae polymerase η.Facile enzymatic synthesis of base J-containing oligodeoxyribonucleotides and an analysis of the impact of base J on DNA replication in cells.Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo Bypass of a 5',8-cyclopurine-2'-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks.The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner Accurate and efficient bypass of 8,5'-cyclopurine-2'-deoxynucleosides by human and yeast DNA polymerase η.Cytotoxic and mutagenic properties of O4-alkylthymidine lesions in Escherichia coli cells.Stability of N-glycosidic bond of (5'S)-8,5'-cyclo-2'-deoxyguanosine.A quantitative assay for assessing the effects of DNA lesions on transcription An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background A high-throughput and quantitative method to assess the mutagenic potential of translesion DNA synthesis.Translesion synthesis of 8,5'-cyclopurine-2'-deoxynucleosides by DNA polymerases η, ι, and ζ.Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions Mass Spectrometry-Based Quantitative Strategies for Assessing the Biological Consequences and Repair of DNA Adducts.6-thioguanine induces mitochondrial dysfunction and oxidative DNA damage in acute lymphoblastic leukemia cells.Replication across regioisomeric ethylated thymidine lesions by purified DNA polymerases.Mutagenicity and genotoxicity of (5'S)-8,5'-cyclo-2'-deoxyadenosine in Escherichia coli and replication of (5'S)-8,5'-cyclopurine-2'-deoxynucleosides in vitro by DNA polymerase IV, exo-free Klenow fragment, and Dpo4.Synthesis of [1,3, NH2-(15)N3] (5'S)-8,5'-cyclo-2'-deoxyguanosine Recent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases.Repair efficiency of (5'S)-8,5'-cyclo-2'-deoxyguanosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine depends on the complementary base.Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.Quantification of Azaserine-Induced Carboxymethylated and Methylated DNA Lesions in Cells by Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method.How does pheomelanin synthesis contribute to melanomagenesis?: Two distinct mechanisms could explain the carcinogenicity of pheomelanin synthesis A high-throughput next-generation sequencing-based method for detecting the mutational fingerprint of carcinogens DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts Chemical Analysis of DNA Damage.Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases.

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High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing.

http://www.wikidata.org/entity/Q30503321

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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Huachuan Cao

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Jianshuang Wang

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Ruobai Sun

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Yinsheng Wang

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P2860

Instability and decay of the primary structure of DNA

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination

A large genome center's improvements to the Illumina sequencing system.

Sequencing technologies - the next generation

Oxidants, oxidative stress and the biology of ageing

The impact of next-generation sequencing technology on genetics

The cancer genome

ChIP-seq: advantages and challenges of a maturing technology

Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.

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