about
Biotechnology. A prudent path forward for genomic engineering and germline gene modificationStructural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylationA Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial ImmunityThe C-terminal region of Ge-1 presents conserved structural features required for P-body localizationStructural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defenseStructures of the tRNA export factor in the nuclear and cytosolic statesStructural insights into the human GW182-PABC interaction in microRNA-mediated deadenylationSequence- and Structure-Specific RNA Processing by a CRISPR EndonucleaseStructural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine SelectivityCoupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA DecayAn RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3Evolution of CRISPR RNA recognition and processing by Cas6 endonucleasesStructures of Cas9 Endonucleases Reveal RNA-Mediated Conformational ActivationStructural basis of PAM-dependent target DNA recognition by the Cas9 endonucleaseRNA-programmed genome editing in human cellsStriking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.Data-collection strategy for challenging native SAD phasingDNA interrogation by the CRISPR RNA-guided endonuclease Cas9.The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.A three-dimensional view of the molecular machinery of RNA interference.An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafishStructural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations.In vitro enzymology of Cas9.Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes.Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA TargetStructural insights into the molecular mechanism of the m(6)A writer complex.Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain.Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe.Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases.Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages.CrispRVariants charts the mutation spectrum of genome engineering experiments.Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9.Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Martin Jinek
@ast
Martin Jinek
@en
Martin Jinek
@es
Martin Jinek
@fr
Martin Jinek
@nl
Martin Jinek
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type
label
Martin Jinek
@ast
Martin Jinek
@en
Martin Jinek
@es
Martin Jinek
@fr
Martin Jinek
@nl
Martin Jinek
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prefLabel
Martin Jinek
@ast
Martin Jinek
@en
Martin Jinek
@es
Martin Jinek
@fr
Martin Jinek
@nl
Martin Jinek
@sl
P106
P1153
6504003856
P21
P31
P496
0000-0002-7601-210X