Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex. - Test2 - elhamkhani - TriplyDB

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.

http://www.wikidata.org/entity/Q30505172

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The pseudo GTPase CENP-M drives human kinetochore assembly Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking Structural basis of Vps33A recruitment to the human HOPS complex by Vps16 Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes Multiple Roles of the Small GTPase Rab7 Coat/Tether Interactions-Exception or Rule?The Secret Life of Tethers: The Role of Tethering Factors in SNARE Complex Regulation Membrane Tethering Complexes in the Endosomal System Rab GTPase regulation of membrane identity Structures and mechanisms of vesicle coat components and multisubunit tethering complexes Function and regulation of the endosomal fusion and fission machineries Vacuoles in mammals: a subcellular structure indispensable for early embryogenesis Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin Detection and characterization of protein interactions in vivo by a simple live-cell imaging method Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles Guanine nucleotide exchange factors (GEFs) have a critical but not exclusive role in organelle localization of Rab GTPases.Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis The HOPS/Class C Vps Complex Tethers High-Curvature Membranes via a Direct Protein-Membrane Interaction.The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3.Subunit organisation of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes The HOPS/class C Vps complex tethers membranes by binding to one Rab GTPase in each apposed membrane.Phosphorylation of the effector complex HOPS by the vacuolar kinase Yck3p confers Rab nucleotide specificity for vacuole docking and fusion.Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport.Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3.Tracking of the dynamic localization of the Rab-specific HOPS subunits reveal their distinct interaction with Ypt7 and vacuoles.Membrane tethering Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.The N-terminal domains of Vps3 and Vps8 are critical for localization and function of the CORVET tethering complex on endosomes.The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVET A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole.Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation.Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex.The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes.Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).

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Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.

http://www.wikidata.org/entity/Q30505172

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2012 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Molecular architecture of the ...... ting (HOPS) tethering complex.

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Anne Kuhlee

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Carina Hönscher

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Christian Ungermann

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Cornelia Bröcker

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Henning J kleine Balderhaar

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Siegfried Engelbrecht-Vandré

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P2860

Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation

The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes

Components of coated vesicles and nuclear pore complexes share a common molecular architecture

Negative staining and image classification — powerful tools in modern electron microscopy

A Structure-Based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1

Structural Evidence for Common Ancestry of the Nuclear Pore Complex and Vesicle Coats

Structure of Coatomer Cage Proteins and the Relationship among COPI, COPII, and Clathrin Vesicle Coats

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

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Christos Gatsogiannis

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221808919

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3277535

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