Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten - Test2 - elhamkhani - TriplyDB

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

http://www.wikidata.org/entity/Q30524175

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Experimental manipulation of radiographic density in mouse mammary gland Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling Genetically engineered mouse models of prostate cancer Cell-type specific roles for PTEN in establishing a functional retinal architecture MicroRNAs are mediators of androgen action in prostate and muscle PI3K/PTEN signaling in angiogenesis and tumorigenesis PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility.Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis The determinants of head and neck cancer: Unmasking the PI3K pathway mutations The role of PTEN in prostate cancer cell tropism to the bone micro-environment.The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes.Muscle-specific Pten deletion protects against insulin resistance and diabetes The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits.Role of vitamin D3 in modulation of ΔNp63α expression during UVB induced tumor formation in SKH-1 mice Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines Conditional deletion of the Pten gene in the mouse prostate induces prostatic intraepithelial neoplasms at early ages but a slow progression to prostate tumors.Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice.Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model.Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma.UVA induces lesions resembling seborrheic keratoses in mice with keratinocyte-specific PTEN downregulation Crosstalking between androgen and PI3K/AKT signaling pathways in prostate cancer cells.Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer.Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.PI3K/mTOR signaling regulates prostatic branching morphogenesis Low expression of phosphatase and tensin homolog in clear‑cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway.Lifelong accumulation of bone in mice lacking Pten in osteoblasts Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice.Akt-regulated pathways in prostate cancer.2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines Genetically engineered murine models of prostate cancer: insights into mechanisms of tumorigenesis and potential utility.Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.PTEN, more than the AKT pathway.Modeling prostate cancer in mice: limitations and opportunities Portrait of PTEN: messages from mutant mice.Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.

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Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

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2004年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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Akira Suzuki

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Otto Sanchez

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William B Chapman

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P2860

p63 is a prostate basal cell marker and is required for prostate development

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

PTEN: one gene, many syndromes

Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

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