Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. - Test2 - elhamkhani - TriplyDB

Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy.

Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy.

http://www.wikidata.org/entity/Q30525675

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IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrus Functional circuits of new neurons in the dentate gyrus The neurology of mTOR PTEN: A master regulator of neuronal structure, function, and plasticity Nogo limits neural plasticity and recovery from injury Turning off AKT: PHLPP as a drug target Suppression of adult neurogenesis increases the acute effects of kainic acid mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia.Conditional Disabled-1 Deletion in Mice Alters Hippocampal Neurogenesis and Reduces Seizure Threshold.Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice Selective neuronal PTEN deletion: can we take the brakes off of growth without losing control?A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory.PTEN knockdown alters dendritic spine/protrusion morphology, not density Grafted Subventricular Zone Neural Stem Cells Display Robust Engraftment and Similar Differentiation Properties and Form New Neurogenic Niches in the Young and Aged Hippocampus Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.Hippocampal granule cell pathology in epilepsy - a possible structural basis for comorbidities of epilepsy?Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction.Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies.Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy.Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure.Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus Is plasticity of GABAergic mechanisms relevant to epileptogenesis?Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline mTOR signaling in epilepsy: insights from malformations of cortical development Olfactory Bulbectomy Leads to the Development of Epilepsy in Mice.From Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer's Disease.Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease.GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.A Retroviral CRISPR-Cas9 System for Cellular Autism-Associated Phenotype Discovery in Developing Neurons.Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity.High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy.

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Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy.

http://www.wikidata.org/entity/Q30525675

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2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年學術文章

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name

Excessive activation of mTOR i ...... sufficient to cause epilepsy.

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Excessive activation of mTOR i ...... sufficient to cause epilepsy.

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Excessive activation of mTOR i ...... sufficient to cause epilepsy.

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Excessive activation of mTOR i ...... sufficient to cause epilepsy.

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Excessive activation of mTOR i ...... sufficient to cause epilepsy.

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Excessive activation of mTOR i ...... sufficient to cause epilepsy.

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J.NEURON.2012.08.002

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Excessive activation of mTOR i ...... sufficient to cause epilepsy.

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Bethany E Hosford

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Brian L Murphy

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Candi L Lasarge

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Christian Faulkner

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Isaiah J Rolle

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Jules M Rosen

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Juli D Uhl

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Katherine D Holland

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Raymund Y K Pun

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Sarah N Schmeltzer

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P2860

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Depression, stress, epilepsy and adult neurogenesis

The recurrent mossy fiber pathway of the epileptic brain

In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

Pten regulates neuronal arborization and social interaction in mice.

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

Pten knockdown in vivo increases excitatory drive onto dentate granule cells

A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice

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1022-1034

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