Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice. - Test2 - elhamkhani - TriplyDB

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.

http://www.wikidata.org/entity/Q30530610

about

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia Neurodegeneration and microtubule dynamics: death by a thousand cuts Hereditary spastic paraplegia SPG4: what is known and not known about the disease.Delving into the complexity of hereditary spastic paraplegias: how unexpected phenotypes and inheritance modes are revolutionizing their nosology Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome.Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia.Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP).Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.Systems genetics implicates cytoskeletal genes in oocyte control of cloned embryo quality.Non-Parkinson movement disorders: Five new things Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development.Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia.Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.Notch signalling in adult neurons: a potential target for microtubule stabilization.Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development.Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin.Motor axon navigation relies on Fidgetin-like 1-driven microtubule plus end dynamics.Patient-Derived Stem Cell Models in HSP: Disease Modelling and Drug Discovery BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation Functional differences of short and long isoforms of spastin harboring missense mutation

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P2860

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.

http://www.wikidata.org/entity/Q30530610

description

2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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Microtubule-targeting drugs re ...... ns from spastin knockout mice.

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Anne Tarrade

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Coralie Fassier

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Cécile Dalard

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Didier Job

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Jamilé Hazan

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Judith Melki

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Julien Lefèvre

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Leticia Peris

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Natacha Roblot

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Patrick A Curmi

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P2860

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus

Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

Human spastin has multiple microtubule-related functions

CLIP-170 links endocytic vesicles to microtubules

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia

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72-83

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10.1242/DMM.008946

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1

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6

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