Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
about
The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouseTargeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviourTranscriptional regulation of the 5-HT1A receptor: implications for mental illnessStimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutationSerotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Sex differences in response to chronic mild stress and congenital serotonin deficiencyAssociations between prefrontal γ-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women.Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expressionImpacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification.Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function micePositron emission tomography quantification of serotonin(1A) receptor binding in suicide attempters with major depressive disorder.Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress.The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system.Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice.Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.Serotonergic transcriptional networks and potential importance to mental health.Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degenerationCortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiencyConservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.The effects of congenital brain serotonin deficiency on responses to chronic fluoxetineSex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice.Peripheral biomarkers in animal models of major depressive disorder.Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice.The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.The adaptive brain in mental health: overcoming inherited risk factors.Increasing the validity of experimental models for depression.Contributions of animal models to the study of mood disorders.Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept.Effects of lisdexamfetamine alone and in combination with s-citalopram on acetylcholine and histamine efflux in the rat pre-frontal cortex and ventral hippocampus.GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice.Metabolomics of Neurotransmitters and Related Metabolites in Post-Mortem Tissue from the Dorsal and Ventral Striatum of Alcoholic Human Brain.Positive regulation of raphe serotonin neurons by serotonin 2B receptors.Neuronal control of experimental colitis occurs via sympathetic intestinal innervation.
P2860
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P2860
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Deficient serotonin neurotrans ...... (Tph2) loss-of-function mice.
@ast
Deficient serotonin neurotrans ...... (Tph2) loss-of-function mice.
@en
type
label
Deficient serotonin neurotrans ...... (Tph2) loss-of-function mice.
@ast
Deficient serotonin neurotrans ...... (Tph2) loss-of-function mice.
@en
prefLabel
Deficient serotonin neurotrans ...... (Tph2) loss-of-function mice.
@ast
Deficient serotonin neurotrans ...... (Tph2) loss-of-function mice.
@en
P2093
P2860
P356
P1433
P1476
Deficient serotonin neurotrans ...... (Tph2) loss-of-function mice.
@en
P2093
J H A Folgering
J P R Jacobsen
S Peterson
W B Siesser
P2860
P2888
P304
P356
10.1038/MP.2011.50
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P577
2011-05-03T00:00:00Z