Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo - Test2 - elhamkhani - TriplyDB

Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo

Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo

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Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6 Arresting serotonin Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice The role of serotonin 5-HT2A receptors in memory and cognition Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder Recent advances in the neuropsychopharmacology of serotonergic hallucinogens Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2 Psychedelics Animal models of serotonergic psychedelics.Is glycogen synthase kinase-3 a central modulator in mood regulation?PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement.Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.G protein-coupled receptors in cardiac biology: old and new receptors Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT)Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Teaching old receptors new tricks: biasing seven-transmembrane receptors.Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists.Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes.Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice.Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response.Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo The potential for selective pharmacological therapies through biased receptor signaling Exploring a role for heteromerization in GPCR signalling specificity.Proteases display biased agonism at protease-activated receptors: location matters!Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse model β-Arrestin-mediated receptor trafficking and signal transduction Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Serotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in Mice

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P2860

Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo

http://www.wikidata.org/entity/Q24647416

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2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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Agonist-directed signaling of ...... rrestin-2 interactions in vivo

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Agonist-directed signaling of ...... rrestin-2 interactions in vivo

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Proceedings of the National Academy of Sciences of the United States of America

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Agonist-directed signaling of ...... rrestin-2 interactions in vivo

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Cullen L Schmid

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Kirsten M Raehal

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice

Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists

A possible correlation between drug-induced hallucinations in man and a behavioural response in mice

1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists

Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior

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1079-1084

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10.1073/PNAS.0708862105

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