IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. - Test2 - elhamkhani - TriplyDB

IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.

IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.

http://www.wikidata.org/entity/Q30538763

about

PCSK9 inhibitors and cardiovascular disease: heralding a new therapeutic era ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.Clathrin-independent endocytosis: a cargo-centric view Cargo recognition in clathrin-mediated endocytosis Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9).The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments.PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice.A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells Molecular pathways: sterols and receptor signaling in cancer.Cellular cholesterol regulates ubiquitination and degradation of the cholesterol export proteins ABCA1 and ABCG1 LDL cholesterol counteracts the antitumour effect of tyrosine kinase inhibitors against renal cell carcinoma.The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning.Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol Foiling IDOL to Help Control Cholesterol.Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones.Clathrin-mediated endocytosis is a candidate entry sorting mechanism for Bombyx mori cypovirus.

P2860

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P2860

IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.

http://www.wikidata.org/entity/Q30538763

description

2013 nî lūn-bûn

@nan

2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

IDOL stimulates clathrin-indep ...... -density lipoprotein receptor.

@ast

IDOL stimulates clathrin-indep ...... -density lipoprotein receptor.

@en

type

label

IDOL stimulates clathrin-indep ...... -density lipoprotein receptor.

@ast

IDOL stimulates clathrin-indep ...... -density lipoprotein receptor.

@en

prefLabel

IDOL stimulates clathrin-indep ...... -density lipoprotein receptor.

@ast

IDOL stimulates clathrin-indep ...... -density lipoprotein receptor.

@en

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P1433

Molecular and Cellular Biology

P1476

IDOL stimulates clathrin-indep ...... -density lipoprotein receptor.

@en

P2093

Alice Y Ting

http://www.w3.org/2001/XMLSchema#string

Chris N Goulbourne

http://www.w3.org/2001/XMLSchema#string

Cynthia Hong

http://www.w3.org/2001/XMLSchema#string

Elena Scotti

http://www.w3.org/2001/XMLSchema#string

Francesco S Pavone

http://www.w3.org/2001/XMLSchema#string

Jinkuk Choi

http://www.w3.org/2001/XMLSchema#string

Li Zhang

http://www.w3.org/2001/XMLSchema#string

Loren G Fong

http://www.w3.org/2001/XMLSchema#string

Martino Calamai

http://www.w3.org/2001/XMLSchema#string

Paul F Pilch

http://www.w3.org/2001/XMLSchema#string

P2860

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII

The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor

Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

P304

1503-1514

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scholarly article

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10.1128/MCB.01716-12

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8

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33

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2013-02-04T00:00:00Z

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23382078

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3624246

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