Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. - Test2 - elhamkhani - TriplyDB

Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.

Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.

http://www.wikidata.org/entity/Q30576923

about

ASICs and cardiovascular homeostasis Two aspects of ASIC function: Synaptic plasticity and neuronal injury.Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis.ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95.Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala.Transient acidosis while retrieving a fear-related memory enhances its lability.ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory.5-HT2A receptor activation is necessary for CO2-induced arousal.ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing.Two di-leucine motifs regulate trafficking and function of mouse ASIC2a.Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms Acid-sensing ion channels are expressed in the ventrolateral medulla and contribute to central chemoreception.ASICs and neuropeptides.ASIC1A in neurons is critical for fear-related behaviors.Amiloride-sensitive cation channel 2 genotype affects the response to a carbon dioxide panic challenge.The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder.Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury.Potentiation and Block of ASIC1a by Memantine.Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population.Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety.Conserved DNA Methylation Signatures in Early Maternal Separation and in Twins Discordant for CO2 Sensitivity.Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC.Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a).Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing.

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Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.

http://www.wikidata.org/entity/Q30576923

description

2013 nî lūn-bûn

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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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P2860

Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)

The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory

Cloning and expression of a novel human brain Na+ channel

BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels

Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior

Structure and activity of the acid-sensing ion channels

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+

The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons

Behavioral despair in mice: a primary screening test for antidepressants

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10.1111/GBB.12108

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