A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. - Test2 - elhamkhani - TriplyDB

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

http://www.wikidata.org/entity/Q30582998

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The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns Rho GTPase signalling in cell migration Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration.Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics Rac1 Regulates Endometrial Secretory Function to Control Placental Development DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.Synonymous modification results in high-fidelity gene expression of repetitive protein and nucleotide sequences.Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion.Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.Optical Tools To Study the Isoform-Specific Roles of Small GTPases in Immune Cells.p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway.Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesis ABL tyrosine kinase inhibition variable effects on the invasive properties of different triple negative breast cancer cell lines.Dysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma.Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics.Modulating the dysregulated migration of pulmonary arterial hypertensive smooth muscle cells with motif mimicking cell permeable peptides Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/MenaINV-initiated invadopodium formation.PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.Digging a little deeper: the stages of invadopodium formation and maturation.Rho GTPase isoforms in cell motility: Don't fret, we have FRET.Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma.Structure, biochemistry, and biology of PAK kinases.Cell adhesion and invasion mechanisms that guide developing axons Expression array analysis of the hepatocyte growth factor invasive program.Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.A new front in cell invasion: The invadopodial membrane.Identification of clinically predictive metagenes that encode components of a network coupling cell shape to transcription by image-omics.Differential role for PAK1 and PAK4 during the invadopodia lifecycle.Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis.Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma.The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis.Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation.The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner.Cortactin function in invadopodia.Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo.

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P2860

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

http://www.wikidata.org/entity/Q30582998

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

@ast

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

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type

label

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

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A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

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prefLabel

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

@ast

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

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Nature Cell Biology

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A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

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John Condeelis

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Jose Javier Bravo-Cordero

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Veronika Miskolci

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Yasmin Moshfegh

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P2860

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

Hallmarks of Cancer: The Next Generation

Localized Rac activation dynamics visualized in living cells

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

A genetically encoded photoactivatable Rac controls the motility of living cells

Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

Epithelial-mesenchymal transitions in tumour progression

Rho GTPases: biochemistry and biology

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