Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest.
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The Vpr protein from HIV-1: distinct roles along the viral life cycleHIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activityHIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation.Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.R77Q and Q3R HIV1-VPR mutations in an otherwise asymptomatic 5-year-old child with repeated ear infectionsHuman immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation.The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding.Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding.Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.Bacterial DNA Protects Monocytic Cells against HIV-Vpr-Induced Mitochondrial Membrane Depolarization.The host-pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domainsThe cysteine residues of HIV-1 capsid regulate oligomerization and cyclophilin A-induced changes.The Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic blockHuman immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.The progestin-only contraceptive medroxyprogesterone acetate, but not norethisterone acetate, enhances HIV-1 Vpr-mediated apoptosis in human CD4+ T cells through the glucocorticoid receptor.Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophagesCellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localizationDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.Vpr cytopathicity independent of G2/M cell cycle arrest in human immunodeficiency virus type 1-infected CD4+ T cellsHIV and apoptosis death and the mitochondrion.Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy.HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesis.Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.HIV1-viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies.Biochemical analyses of the interactions between human immunodeficiency virus type 1 Vpr and p6(Gag).Adipose Tissue in HIV Infection.Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin.Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes.Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.HIV-1 Vpr Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Inducing MicroRNA miR-942-5p and Activating NF-κB SignalingSpecific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status.The cationic amphipathic alpha-helix of HIV-1 viral protein R (Vpr) binds to nucleic acids, permeabilizes membranes, and efficiently transfects cells.HIV-1 infection and the PPARγ-dependent control of adipose tissue physiologyIn Silico Investigation of a HIV-1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti-HIV Drug Design.Mutation of the highly conserved Ser-40 of the HIV-1 p6 gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag.A role of disordered domains in regulating protein oligomerization and stability.HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD.
P2860
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P2860
Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Functional and structural char ...... induces G2 cell cycle arrest.
@ast
Functional and structural char ...... induces G2 cell cycle arrest.
@en
type
label
Functional and structural char ...... induces G2 cell cycle arrest.
@ast
Functional and structural char ...... induces G2 cell cycle arrest.
@en
prefLabel
Functional and structural char ...... induces G2 cell cycle arrest.
@ast
Functional and structural char ...... induces G2 cell cycle arrest.
@en
P2093
P2860
P356
P1476
Functional and structural char ...... induces G2 cell cycle arrest.
@en
P2093
Henklein P
Schubert U
Sherman MP
de Noronha CM
P2860
P304
32016-32026
P356
10.1074/JBC.M004044200
P407
P577
2000-10-01T00:00:00Z