Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library.
about
Targeting UDP-galactopyranose mutases from eukaryotic human pathogensLigand Binding and Substrate Discrimination by UDP-Galactopyranose MutaseVirtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial AgentsA dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosisSolid-phase synthesis of a thymidinyl dipeptide urea libraryHigh-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens.Targeting the formation of the cell wall core of M. tuberculosis.Natural product growth inhibitors of Mycobacterium tuberculosis.Investigation of binding of UDP-Galf and UDP-[3-F]Galf to UDP-galactopyranose mutase by STD-NMR spectroscopy, molecular dynamics, and CORCEMA-ST calculations.Chemical methods for degradation of target oligosaccharides using designed light-activatable organic molecules.Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules.Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules.Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates.Substrate-dependent dynamics of UDP-galactopyranose mutase: Implications for drug design.Carboxylate Surrogates Enhance the Antimycobacterial Activity of UDP-Galactopyranose Mutase Probes.Development of new antituberculous agents based on new drug targets and structure-activity relationship.Natural and Synthetic Flavonoids as Potent Mycobacterium tuberculosis UGM Inhibitors.Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite.Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.Synthesis and analysis of substrate analogues for UDP-galactopyranose mutase: implication for an oxocarbenium ion intermediate in the catalytic mechanism.Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease.UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase.Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases.Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis.Identification of Novel Inhibitors of UDP-Galactopyranose Mutase by Structure-Based Virtual Screening.
P2860
Q26862107-402122D5-8670-4EC1-BDB5-BDFB03AF9F05Q27655753-3330FF52-A3F7-4417-BD9D-7F9FE8F1FD0AQ27657362-17080CCA-97CF-401F-91EB-1123E477C518Q28485999-7F2C0C4E-463C-4A46-9054-9815CED115B1Q33281490-920518C7-0961-4EFC-B594-2B5DA9A1022FQ33503956-7AB394D9-2729-4211-AE9E-B9183430AE90Q33856548-D8700253-E131-4B12-866B-D9B6762384CFQ36561313-54061976-937F-4133-A974-F428465FA586Q36772385-DF67FEDB-4CD2-4E8D-A937-CF0B705F7BA7Q37457660-D5533F78-DD19-4667-9435-BF58768EA8D1Q37989395-B883185A-88F6-4F5F-9527-A64157288003Q38068131-02F210B7-0F62-4C6C-95B3-A66D4DA8C312Q38443096-ECF72C43-65F3-4D90-A2E6-D765FAD23AB6Q38541158-17B08C72-8667-4DFC-B43E-B0CA5F830D11Q38912866-15428EF2-D99A-4074-838E-D6CF46F2C73EQ39392401-BA157411-64BD-448E-8872-80A01A448F7CQ40138610-A54D3B93-124A-4BA7-AF04-AF1A4B60CC48Q40215766-F3E79D96-7940-4CC4-BF69-D6CD38816FA5Q41479001-5BCD3D5C-C58D-4BCA-A115-AC84982D878AQ41771088-8A3A7F11-D9A4-4914-8A2A-397EDDAA3B3AQ42390505-4FCA88DA-3CE4-4F9E-B8FC-95B0D5DE6D21Q42752718-59F1DC9D-3D68-4967-990B-C6FCD4D79AC2Q45925604-5B1743DA-2D46-47F9-B574-669202B41250Q46737594-E04E3D10-7B1F-4E29-80FD-A792B1641173Q53635604-7344E51F-53C1-4AF0-B68B-1C918BBB1546Q54352039-A5118CC8-B904-4CB3-8D75-114F77C9F4CB
P2860
Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Drug targeting Mycobacterium t ...... from a uridine-based library.
@ast
Drug targeting Mycobacterium t ...... from a uridine-based library.
@en
type
label
Drug targeting Mycobacterium t ...... from a uridine-based library.
@ast
Drug targeting Mycobacterium t ...... from a uridine-based library.
@en
prefLabel
Drug targeting Mycobacterium t ...... from a uridine-based library.
@ast
Drug targeting Mycobacterium t ...... from a uridine-based library.
@en
P2093
P2860
P1476
Drug targeting Mycobacterium t ...... from a uridine-based library.
@en
P2093
Carolyn R Bertozzi
Katharine A Winans
Michael R McNeil
Michael S Scherman
Richard J Stern
Victoria Jones
P2860
P304
P356
10.1128/AAC.47.1.378-382.2003
P407
P577
2003-01-01T00:00:00Z