Why does threonine, and not serine, function as the active site nucleophile in proteasomes?
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Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triadElucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate HydrolysisRad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domainThe ATP-dependent CodWX (HslVU) protease in Bacillus subtilis is an N-terminal serine proteaseThe caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization.Broad targeting of resistance to apoptosis in cancer.A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies.Fundamental reaction pathway for peptide metabolism by proteasome: insights from first-principles quantum mechanical/molecular mechanical free energy calculationsArchaeal proteasomes and sampylation.Pharmacophore modeling technique applied for the discovery of proteasome inhibitors.Bacterial and Fungal Proteolytic Enzymes: Production, Catalysis and Potential Applications.A mathematical model of protein degradation by the proteasome.The MUC1 SEA module is a self-cleaving domain.Protein association and dissociation regulated by extension peptide: a mode for iron control by phytoferritin in seeds.Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.Growth-associated protein of 43 kDa (GAP-43) is cleaved nonprocessively by the 20S proteasome.Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome.Evidence for the direct involvement of the proteasome in the proteolytic processing of the Aspergillus nidulans zinc finger transcription factor PacC.A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea.
P2860
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P2860
Why does threonine, and not serine, function as the active site nucleophile in proteasomes?
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Why does threonine, and not se ...... te nucleophile in proteasomes?
@ast
Why does threonine, and not se ...... te nucleophile in proteasomes?
@en
type
label
Why does threonine, and not se ...... te nucleophile in proteasomes?
@ast
Why does threonine, and not se ...... te nucleophile in proteasomes?
@en
prefLabel
Why does threonine, and not se ...... te nucleophile in proteasomes?
@ast
Why does threonine, and not se ...... te nucleophile in proteasomes?
@en
P2093
P2860
P356
P1476
Why does threonine, and not se ...... te nucleophile in proteasomes?
@en
P2093
Goldberg AL
Kisselev AF
Songyang Z
P2860
P304
14831-14837
P356
10.1074/JBC.275.20.14831
P407
P577
2000-05-01T00:00:00Z