Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.
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The N-end rule pathwayMouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcriptionStructural basis of substrate recognition and specificity in the N-end rule pathwayLiat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeatsAltered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesisUbiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndromeProtein arginylation, a global biological regulator that targets actin cytoskeleton and the muscleA neurostimulant para-chloroamphetamine inhibits the arginylation branch of the N-end rule pathway.The N-end rule pathway and regulation by proteolysisCharacterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytesThe N-end rule pathway counteracts cell death by destroying proapoptotic protein fragmentsPharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.Ablation of Arg-tRNA-protein transferases results in defective neural tube development.The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.Posttranslational arginylation as a global biological regulator.Post-translational protein arginylation in the normal nervous system and in neurodegeneration.Physiological functions and clinical implications of the N-end rule pathway.Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.Protein arginylation regulates cellular stress response by stabilizing HSP70 and HSP40 transcripts.Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins.Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway.The placental interleukin-6 signaling controls fetal brain development and behavior.A reference-based protein degradation assay without global translation inhibitors.The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology
P2860
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P2860
Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Ablation of arginylation in th ...... nd neurological perturbations.
@ast
Ablation of arginylation in th ...... nd neurological perturbations.
@en
type
label
Ablation of arginylation in th ...... nd neurological perturbations.
@ast
Ablation of arginylation in th ...... nd neurological perturbations.
@en
prefLabel
Ablation of arginylation in th ...... nd neurological perturbations.
@ast
Ablation of arginylation in th ...... nd neurological perturbations.
@en
P2860
P1433
P1476
Ablation of arginylation in th ...... nd neurological perturbations.
@en
P2093
Alexander Varshavsky
Christopher S Brower
P2860
P356
10.1371/JOURNAL.PONE.0007757
P407
P577
2009-11-13T00:00:00Z