Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.

Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.

Item
http://www.wikidata.org/entity/Q31034495
Transition-state inhibitors of purine salvage and other prospective enzyme targets in malariaComputational perspectives into plasmepsins structure-function relationship: implications to inhibitors design.Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C.The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.The impact of microwave synthesis on drug discovery.Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors.Probing the effect of point mutations at protein-protein interfaces with free energy calculationsPlasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis.Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy.The role of Plasmodium falciparum food vacuole plasmepsins.X-ray structure of plasmepsin II complexed with a potent achiral inhibitor.Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human cathepsin D.Replacement of isobutyl by trifluoromethyl in pepstatin A selectively affects inhibition of aspartic proteinases.Multiple target-based pharmacophore design from active site structures.
P2860

Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.

Item
http://www.wikidata.org/entity/Q31034495
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Potent inhibitors of the Plasm ...... thepsin D inhibitory activity.
@ast
Potent inhibitors of the Plasm ...... thepsin D inhibitory activity.
@en
type
label
Potent inhibitors of the Plasm ...... thepsin D inhibitory activity.
@ast
Potent inhibitors of the Plasm ...... thepsin D inhibitory activity.
@en
prefLabel
Potent inhibitors of the Plasm ...... thepsin D inhibitory activity.
@ast
Potent inhibitors of the Plasm ...... thepsin D inhibitory activity.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Potent inhibitors of the Plasm ...... thepsin D inhibitory activity.
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921