The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.
about
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.From crystal to compound: structure-based antimalarial drug discovery.M1 aminopeptidases as drug targets: broad applications or therapeutic niche?Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases.Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.Sitagliptin does not inhibit the M1 alanyl aminopeptidase from Plasmodium falciparum.
P2860
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P2860
The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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2012年论文
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name
The aminopeptidase inhibitor C ...... e inhibitor of murine malaria.
@ast
The aminopeptidase inhibitor C ...... e inhibitor of murine malaria.
@en
type
label
The aminopeptidase inhibitor C ...... e inhibitor of murine malaria.
@ast
The aminopeptidase inhibitor C ...... e inhibitor of murine malaria.
@en
prefLabel
The aminopeptidase inhibitor C ...... e inhibitor of murine malaria.
@ast
The aminopeptidase inhibitor C ...... e inhibitor of murine malaria.
@en
P2093
P2860
P356
P1476
The aminopeptidase inhibitor C ...... e inhibitor of murine malaria.
@en
P2093
Christopher L Brown
Christopher L Peatey
Colin Stack
David Krige
Desire M M Nsangou
Donald L Gardiner
John P Dalton
Karen Anderson
Karine Thivierge
Katharine R Trenholme
P2860
P304
P356
10.1128/AAC.06245-11
P407
P577
2012-03-26T00:00:00Z