Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen
about
Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies.The structural basis of repertoire shift in an immune response to phosphocholineA method of estimating the numbers of human and mouse immunoglobulin V-genesExtreme genetic fragility of the HIV-1 capsid.Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factorsIn situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cellsDefective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2.Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.Natural autoantibodies and associated B cells in immunity and autoimmunity.Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse.Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis.Immune Repertoire after Immunization As Seen by Next-Generation Sequencing and Proteomics.The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.IgG+, CD5+ human chronic lymphocytic leukemia B cells. Production of IgG antibodies that exhibit diminished autoreactivity and IgG subclass skewing.Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used
P2860
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P2860
Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen
description
1992 nî lūn-bûn
@nan
1992 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Generation and analysis of ran ...... their ability to bind antigen
@ast
Generation and analysis of ran ...... their ability to bind antigen
@en
type
label
Generation and analysis of ran ...... their ability to bind antigen
@ast
Generation and analysis of ran ...... their ability to bind antigen
@en
prefLabel
Generation and analysis of ran ...... their ability to bind antigen
@ast
Generation and analysis of ran ...... their ability to bind antigen
@en
P2093
P2860
P356
P1476
Generation and analysis of ran ...... their ability to bind antigen
@en
P2093
M B Rittenberg
V A Roberts
P2860
P304
P356
10.1084/JEM.176.3.855
P407
P577
1992-09-01T00:00:00Z