The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site
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Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligandsInsights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolutionIg Constant Region Effects on Variable Region Structure and FunctionEngineered hapten-binding antibody derivatives for modulation of pharmacokinetic properties of small molecules and targeted payload deliveryThe structural basis of repertoire shift in an immune response to phosphocholineStructure of the male determinant factor for Brassica self-incompatibilityDefining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigenStructure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulationStructure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complexAmino acid sequence of the Fv region of a human monoclonal IgM (protein WEA) with antibody activity against 3,4-pyruvylated galactose in Klebsiella polysaccharides K30 and K33The combining site of the dinitrophenyl-binding immunoglobulin A myeloma protein MOPC 315Specificity of mouse hybridoma antibodies to DNA. III. Antigenic determinants of nucleic acids recognized by poly(dG) specific monoclonal antibodiesNatural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunityRecognition and interactions controlling the assemblies of beta barrel domains.Secondary structure of the immunoglobulin J chainStructural invariants of antigen binding: comparison of immunoglobulin VL-VH and VL-VL domain dimersEvidence supporting somatic assembly of the DNA segments (minigenes), coding for the framework, and complementarity-determining segments of immunoglobulin variable regions.Nucleotide sequences and three-dimensional modelling of the VH and VL domains of two human monoclonal antibodies specific for the D antigen of the human Rh-blood-group system.Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenProtein engineering of antibodies.Dual conformations of an immunoglobulin light-chain dimer: heterogeneity of antigen specificity and idiotope profile may result from multiple variable-domain interaction mechanismsMapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis.A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretionModelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitopeThree distinct epitopes within the loop region of hen egg lysozyme defined with monoclonal antibodies.Nucleotide sequences of five anti-lysozyme monoclonal antibodiesSome sequence similarities among cloned mouse DNA segments that code for lambda and kappa light chains of immunoglobulins.Symmetry of Fv architecture is conducive to grafting a second antibody binding site in the Fv region.Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chains.Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteinsStructure-function relations in phosphorylcholine-binding mouse myeloma proteins.Some correlations between specificity and sequence of the first complementarity-determining segments of human kappa light chains.Crystallographic studies of bovine beta2-microglobulin.Antigen-binding mutants of mouse myeloma cells.Three-dimensional structure of an intact human immunoglobulinAmino acid sequence of the first 217 residues of a mouse heavy chain (MOPC 47A) with a domain deletion.Structural implications of sequence variability in immunoglobulins.Variability of three-dimensional structure in immunoglobulins.Antigen-induced conformational changes in antibodies and their Fab fragments studied by circular polarization of fluorescence.
P2860
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P2860
The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site
description
1974 nî lūn-bûn
@nan
1974 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1974 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1974年の論文
@ja
1974年論文
@yue
1974年論文
@zh-hant
1974年論文
@zh-hk
1974年論文
@zh-mo
1974年論文
@zh-tw
1974年论文
@wuu
name
The three-dimensional structur ...... re of the antigen binding site
@ast
The three-dimensional structur ...... re of the antigen binding site
@en
type
label
The three-dimensional structur ...... re of the antigen binding site
@ast
The three-dimensional structur ...... re of the antigen binding site
@en
prefLabel
The three-dimensional structur ...... re of the antigen binding site
@ast
The three-dimensional structur ...... re of the antigen binding site
@en
P2093
P2860
P356
P1476
The three-dimensional structur ...... re of the antigen binding site
@en
P2093
P2860
P304
P356
10.1073/PNAS.71.11.4298
P407
P577
1974-11-01T00:00:00Z