Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
about
The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRsFluorescent approaches for understanding interactions of ligands with G protein coupled receptorsAdenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.Portraying G protein-coupled receptors with fluorescent ligandsApplication of BRET to monitor ligand binding to GPCRs.Fragment-based lead discovery on G-protein-coupled receptors.Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.Fluorescent ligands for adenosine receptors.Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding.Structure-based and fragment-based GPCR drug discovery.Biophysical Detection of Diversity and Bias in GPCR Function.Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging.Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary.Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors.Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexesEffect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.Fluorescent ligands for G protein-coupled receptors: illuminating receptor-ligand interactions for drug discovery.Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: a construction kit for fluorescent labeling of receptor ligands.Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells.A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells.Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging.
P2860
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P2860
Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Fragment screening at adenosin ...... orescence-based binding assay.
@ast
Fragment screening at adenosin ...... orescence-based binding assay.
@en
type
label
Fragment screening at adenosin ...... orescence-based binding assay.
@ast
Fragment screening at adenosin ...... orescence-based binding assay.
@en
prefLabel
Fragment screening at adenosin ...... orescence-based binding assay.
@ast
Fragment screening at adenosin ...... orescence-based binding assay.
@en
P2093
P2860
P1476
Fragment screening at adenosin ...... orescence-based binding assay.
@en
P2093
Andrea J Vernall
Barrie Kellam
Jessica L Denman
Leigh A Stoddart
P2860
P304
P356
10.1016/J.CHEMBIOL.2012.07.014
P577
2012-09-01T00:00:00Z