The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors.
about
Snake Venom: Any Clue for Antibiotics and CAM?Strategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONEDesign, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 CarbapenemaseDesign, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as β-Lactamase Inhibitorsβ-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-EnzymeInhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.Model-based analysis and optimization of bioreactor for hematopoietic stem cell cultivation.The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.Penicillin sulfone inhibitors of class D beta-lactamasesApproaches to the simultaneous inactivation of metallo- and serine-beta-lactamases.Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.Matrix-assisted laser desorption ionization-time of flight (maldi-tof) mass spectrometry for detection of antibiotic resistance mechanisms: from research to routine diagnosisDesigning Irreversible Inhibitors--Worth the Effort?Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone.Natural products to drugs: natural product derived compounds in clinical trials.In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor.Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids.Exploiting bacterial iron acquisition: siderophore conjugates.Catechol-based biomimetic functional materials.FvtA is the receptor for the siderophore vanchrobactin in Vibrio anguillarum: utility as a route of entry for vanchrobactin analoguesActivity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfoneLN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.Asymmetric Mannich reaction of fluorinated ketoesters with a tryptophan-derived bifunctional thiourea catalyst.Permeability of a novel beta-lactamase inhibitor LK-157 and its ester prodrugs across rat jejunum in vitro.Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance.Retrospective evaluation of a possible interaction between warfarin and levofloxacin.Synthesis and biological activity of analogues of vanchrobactin, a siderophore from Vibrio anguillarum serotype O2.Cycloreversion of β-lactams via photoinduced electron transfer.Ring splitting of azetidin-2-ones via radical anions.Highly diastereoselective entry into chiral spirooxindole-based 4-methyleneazetidines via formal [2+2] annulation reaction
P2860
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P2860
The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The discovery and development ...... ved beta-lactamase inhibitors.
@ast
The discovery and development ...... ved beta-lactamase inhibitors.
@en
type
label
The discovery and development ...... ved beta-lactamase inhibitors.
@ast
The discovery and development ...... ved beta-lactamase inhibitors.
@en
prefLabel
The discovery and development ...... ved beta-lactamase inhibitors.
@ast
The discovery and development ...... ved beta-lactamase inhibitors.
@en
P356
P1476
The discovery and development ...... ved beta-lactamase inhibitors.
@en
P2093
John D Buynak
P304
P356
10.2174/0929867043364847
P577
2004-07-01T00:00:00Z