Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. - Test2 - elhamkhani - TriplyDB

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

http://www.wikidata.org/entity/Q34361517

about

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes Diversity-oriented synthesis yields novel multistage antimalarial inhibitors Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.Neuroprotective Effect of 3-(Naphthalen-2-Yl(Propoxy)Methyl)Azetidine Hydrochloride on Brain Ischaemia/Reperfusion Injury.3-Aryl-3-arylmethoxyazetidines. A new class of high affinity ligands for monoamine transporters.Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.Protective effect of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on hypoxia-induced toxicity by suppressing microglial activation in BV-2 cells.Hits, leads and drugs against malaria through diversity-oriented synthesis.Transition metal-free one-pot synthesis of nitrogen-containing heterocycles.Synthesis of azetidines and pyrrolidines via iodocyclisation of homoallyl amines and exploration of activity in a zebrafish embryo assay.Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)-H Arylation.Drug discovery: Chemical diversity targets malaria.Studies on the interaction of isocyanides with imines: reaction scope and mechanistic variations Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides Rapid assembly of functionalised spirocyclic indolines by palladium-catalysed dearomatising diallylation of indoles with allyl acetate.Anti-inflammatory and anti-oxidative effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on β-amyloid-induced microglial activation.Facile Synthesis of Azetidine Nitrones and Diastereoselective Conversion into Densely Substituted Azetidines.Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.Evaluierung neuer Reaktionen zur Steuerung der Wirkstoff-Forschung: ein Eignungstest Recent updates in the discovery and development of novel antimalarial drug candidates Ring Expansion of Bicyclic Methyleneaziridines via Concerted, Near-Barrierless [2,3]-Stevens Rearrangements of Aziridinium Ylides Highly diastereoselective entry into chiral spirooxindole-based 4-methyleneazetidines via formal [2+2] annulation reaction Densely Functionalized 2-Methylideneazetidines from Nitrodienic Building Blocks

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Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

http://www.wikidata.org/entity/Q34361517

description

2012 nî lūn-bûn

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2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2012 թվականի օգոստոսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Synthesis and profiling of a d ...... S-focused lead-like libraries.

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Journal of Organic Chemistry

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Synthesis and profiling of a d ...... NS-focused lead-like libraries

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P2093

Adrien Joliton

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Ann Rowley

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Baudouin Gerard

http://www.w3.org/2001/XMLSchema#string

Berenice C Lemercier

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Byung-Chul Suh

http://www.w3.org/2001/XMLSchema#string

Carol A Mulrooney

http://www.w3.org/2001/XMLSchema#string

Edward B Holson

http://www.w3.org/2001/XMLSchema#string

Emeline Davoine

http://www.w3.org/2001/XMLSchema#string

Florence F Wagner

http://www.w3.org/2001/XMLSchema#string

Giovanni Muncipinto

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P2860

Target-oriented and diversity-oriented organic synthesis in drug discovery

NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

A planning strategy for diversity-oriented synthesis

Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam

Antibacterial natural products in medicinal chemistry--exodus or revival?

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Libraries from natural product-like scaffolds.

The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors.

A similarity-based data-fusion approach to the visual characterization and comparison of compound databases.

A library of spirooxindoles based on a stereoselective three-component coupling reaction.

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7187-7211

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scholarly article

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10.1021/JO300974J

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P433

17

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P478

77

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Etienne Donckele

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2012-08-10T00:00:00Z

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230594135

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22853001

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3454511

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