Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.
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A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulationMultiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesisIntegrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signalingAngiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migrationChanges in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancerIntegrin 3 Phosphorylation Dictates Its Complex with the Shc Phosphotyrosine-binding (PTB) Domainp21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migrationThe PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targetsPhosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassemblyCD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance.Phosphosignature predicts dasatinib response in non-small cell lung cancer.Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.Integrin α6A splice variant regulates proliferation and the Wnt/β-catenin pathway in human colorectal cancer cells.Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation.Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells.The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis.Androgen receptor and prostate cancer invasion.Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.Analysis on the relevance of asthma susceptibility with the alteration of integrin β 4 expressionRole of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migrationIntegrin β4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF.PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736.Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells.p66Shc mediates anoikis through RhoAInvasive breast cancer induces laminin-332 upregulation and integrin β4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype during tissue remodeling.An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer.Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion.The calcium/calcineurin pathway promotes hemidesmosome stability through inhibition of β4 integrin phosphorylation.Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.Compartmentalization of integrin alpha6beta4 signaling in lipid raftsβ4 Integrin signaling induces expansion of prostate tumor progenitorsDistinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasisA key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression.A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4.Integrins in angiogenesis and lymphangiogenesisDynamic Regulation of Integrin α6β4 During Angiogenesis: Potential Implications for Pathogenic Wound HealingCoordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.Roles of integrins in tumor angiogenesis and lymphangiogenesis.
P2860
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P2860
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Tyrosine phosphorylation of th ...... s formation of hemidesmosomes.
@ast
Tyrosine phosphorylation of th ...... s formation of hemidesmosomes.
@en
type
label
Tyrosine phosphorylation of th ...... s formation of hemidesmosomes.
@ast
Tyrosine phosphorylation of th ...... s formation of hemidesmosomes.
@en
prefLabel
Tyrosine phosphorylation of th ...... s formation of hemidesmosomes.
@ast
Tyrosine phosphorylation of th ...... s formation of hemidesmosomes.
@en
P2093
P2860
P356
P1476
Tyrosine phosphorylation of th ...... s formation of hemidesmosomes.
@en
P2093
Gagnoux-Palacios L
Giancotti FG
Mariotti A
P2860
P304
P356
10.1074/JBC.M008663200
P407
P577
2001-01-01T00:00:00Z