Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
about
Structural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3Are transversion mutations better? A Mutagenesis Assistant Program analysis on P450 BM-3 heme domain.Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.Cytochrome P450 enzymes in the generation of commercial products.The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity.Sensitive assay for laboratory evolution of hydroxylases toward aromatic and heterocyclic compounds.Laboratory-directed protein evolutionAnalysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis.Laboratory evolution of P450 BM-3 for mediated electron transfer.Expanding the substrate scope of enzymes: combining mutations obtained by CASTing.A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.Progress towards the easier use of P450 enzymes.Computational tools for rational protein engineering of aldolases.Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutantsEnantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects.P450(BM3) (CYP102A1): connecting the dots.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Learning from directed evolution: Further lessons from theoretical investigations into cooperative mutations in lipase enantioselectivity.Engineering cytochrome P450 BM-3 for oxidation of polycyclic aromatic hydrocarbons.Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution.Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7.Residue size at position 87 of cytochrome P450 BM-3 determines its stereoselectivity in propylbenzene and 3-chlorostyrene oxidation.Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents.Hydroxylation activity of P450 BM-3 mutant F87V towards aromatic compounds and its application to the synthesis of hydroquinone derivatives from phenolic compounds.Structural and dynamic properties of cytochrome P450 BM-3 in pure water and in a dimethylsulfoxide/water mixture.Biotransformation of beta-ionone by engineered cytochrome P450 BM-3.Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3.Selective hydroxylation of highly branched fatty acids and their derivatives by CYP102A1 from Bacillus megaterium.Biological chemistry: enzymes in focus.Enantioselective Allylic Hydroxylation of ω-Alkenoic Acids and Esters by P450 BM3 MonooxygenaseEnantioselektive allylische Hydroxylierung von ω-Alkensäuren und -estern mittels der P450-BM3-Monooxygenase
P2860
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P2860
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
@ast
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
@en
type
label
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
@ast
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
@en
prefLabel
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
@ast
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.
@en
P2093
P1476
Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant
@en
P2093
P304
P356
10.1016/S0167-4838(00)00268-5
P407
P577
2001-02-01T00:00:00Z