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Electron flow through biological molecules: does hole hopping protect proteins from oxidative damage?Expanding P450 catalytic reaction space through evolution and engineeringA novel type of allosteric regulation: functional cooperativity in monomeric proteinsOptimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolitesThe crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate BiasThe crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding siteImproving the affinity and activity of CYP101D2 for hydrophobic substratesInvestigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineeringP450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidationStructural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3A single mutation at the ferredoxin binding site of P450 Vdh enables efficient biocatalytic production of 25-hydroxyvitamin D(3)Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3The structure of a novel electron-transfer ferredoxin from Rhodopseudomonas palustris HaA2 which contains a histidine residue in its iron-sulfur cluster-binding motifThe crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilisInsights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculationsOlefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 EnzymesStructural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450.Beyond Iron: Iridium-Containing P450 Enzymes for Selective Cyclopropanations of Structurally Diverse Alkenes.Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipranCharacterization of Cupriavidus metallidurans CYP116B1--a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.Regio- and stereoselective hydroxylation of 10-undecenoic acid with a light-driven P450 BM3 biocatalyst yielding a valuable synthon for natural product synthesis.A series of hybrid P450 BM3 enzymes with different catalytic activity in the light-initiated hydroxylation of lauric acidHeme enzyme structure and function.Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination.Improving the activity of cytochrome P450 BM-3 catalyzing indole hydroxylation by directed evolution.Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins.Could tyrosine and tryptophan serve multiple roles in biological redox processes?Economical analysis of saturation mutagenesis experiments.Drug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants.Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.Expanding an Efficient, Electrically Driven and CNT-Tagged P450 System into the Third Dimension: A Nanowired CNT-Containing and Enzyme-Stabilising 3 D Sol-Gel Electrode.Semirational Protein Engineering of CYP153AM.aq. -CPRBM3 for Efficient Terminal Hydroxylation of Short- to Long-Chain Fatty Acids.Regioselective C-H hydroxylation of omeprazole sulfide by Bacillus megaterium CYP102A1 to produce a human metabolite.Keeping the spotlight on cytochrome P450.Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivityRu(II)-diimine functionalized metalloproteins: From electron transfer studies to light-driven biocatalysis.Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
P450(BM3) (CYP102A1): connecting the dots.
@en
type
label
P450(BM3) (CYP102A1): connecting the dots.
@en
prefLabel
P450(BM3) (CYP102A1): connecting the dots.
@en
P2860
P356
P1476
P450(BM3) (CYP102A1): connecting the dots
@en
P2093
Christopher J C Whitehouse
Luet-Lok Wong
P2860
P304
P356
10.1039/C1CS15192D
P577
2011-10-18T00:00:00Z