The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain.
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Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitinationMolecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10pDysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagensAriadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteinsBinding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complexThe RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutationBRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactionsEnhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 proteinDimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif.The ubiquitin system, disease, and drug discovery.The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.Self-assembly properties of a model RING domainBRCA1 physically and functionally interacts with ATF1.Substitution of glutamate residue by lysine in the dimerization domain affects DNA binding ability of HapR by inducing structural deformity in the DNA binding domainCharacterization of an Italian founder mutation in the RING-finger domain of BRCA1.The BRCA1 variant p.Ser36Tyr abrogates BRCA1 protein function and potentially confers a moderate risk of breast cancer.Identification of a novel effector domain of BIN1 for cancer suppression.Classification of BRCA1 missense variants of unknown clinical significance.Functional assays for BRCA1 and BRCA2.Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds.Ubiquitin ligases in cancer: ushers for degradation.Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistanceHost Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1.The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein.Role of BRCA1 in heat shock response.Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.High prevalence of BRCA1 founder mutations in Greek breast/ovarian families.
P2860
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P2860
The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain.
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The cancer-predisposing mutati ...... inal BRCA1 RING finger domain.
@ast
The cancer-predisposing mutati ...... inal BRCA1 RING finger domain.
@en
type
label
The cancer-predisposing mutati ...... inal BRCA1 RING finger domain.
@ast
The cancer-predisposing mutati ...... inal BRCA1 RING finger domain.
@en
prefLabel
The cancer-predisposing mutati ...... inal BRCA1 RING finger domain.
@ast
The cancer-predisposing mutati ...... inal BRCA1 RING finger domain.
@en
P2093
P2860
P356
P1476
The cancer-predisposing mutati ...... inal BRCA1 RING finger domain.
@en
P2093
P2860
P304
P356
10.1074/JBC.273.14.7795
P407
P577
1998-04-01T00:00:00Z