about
A guide for functional analysis of BRCA1 variants of uncertain significanceThe expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approachFunctional impact of missense variants in BRCA1 predicted by supervised learningProbing structure-function relationships in missense variants in the carboxy-terminal region of BRCA1Assessment of human Nter and Cter BRCA1 mutations using growth and localization assays in yeast.Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.A computational method to classify variants of uncertain significance using functional assay data with application to BRCA1Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis.Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.Functional and structural analysis of C-terminal BRCA1 missense variants.Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2.Increased expression of DNA repair genes in invasive human pancreatic cancer cells.A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin.Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.Cancer predisposing mutations in BRCT domains.The impact of next generation sequencing on the analysis of breast cancer susceptibility: a role for extremely rare genetic variation?Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway.Genome annotation by shotgun inactivation of a native gene in hemizygous cells: application to BRCA2 with implication of hypomorphic variants.Multimodel assessment of BRCA1 mutations in Taiwanese (ethnic Chinese) women with early-onset, bilateral or familial breast cancer.Prediction of breast cancer risk based on flow-variant analysis of circulating peripheral blood B cells.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Functional assays for BRCA1 and BRCA2.
@ast
Functional assays for BRCA1 and BRCA2.
@en
type
label
Functional assays for BRCA1 and BRCA2.
@ast
Functional assays for BRCA1 and BRCA2.
@en
prefLabel
Functional assays for BRCA1 and BRCA2.
@ast
Functional assays for BRCA1 and BRCA2.
@en
P2860
P1476
Functional assays for BRCA1 and BRCA2.
@en
P2093
Marcelo A Carvalho
P2860
P304
P356
10.1016/J.BIOCEL.2006.08.002
P577
2006-08-18T00:00:00Z