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Janus kinases in immune cell signalingTYK2 is a key regulator of the surveillance of B lymphoid tumorsRelB-dependent stromal cells promote T-cell leukemogenesisSocs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.Jak2 inhibitors: rationale and role as therapeutic agents in hematologic malignancies.Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors.The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-AblTransforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase.Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient miceEnhanced T cell lymphoma in NOD.Stat5b transgenic mice is caused by hyperactivation of Stat5b in CD8+ thymocytes.Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.The role of Tyk2 in regulation of breast cancer growth.Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.JAK Kinases in Health and Disease: An UpdateA Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signalingAlternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafishZ3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.Targeting signal transducer and activator of transcription signaling pathway in leukemias.Molecular drug targets in myeloproliferative neoplasms: mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1.Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses.The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.Modeling ETV6-JAK2-induced leukemia: insights from the zebrafish.NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells.Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
TEL-JAK2 transgenic mice develop T-cell leukemia.
@ast
TEL-JAK2 transgenic mice develop T-cell leukemia.
@en
type
label
TEL-JAK2 transgenic mice develop T-cell leukemia.
@ast
TEL-JAK2 transgenic mice develop T-cell leukemia.
@en
prefLabel
TEL-JAK2 transgenic mice develop T-cell leukemia.
@ast
TEL-JAK2 transgenic mice develop T-cell leukemia.
@en
P2093
P50
P1433
P1476
TEL-JAK2 transgenic mice develop T-cell leukemia
@en
P2093
Ghysdael J
Giovannini M
Lacronique V
P304
P407
P577
2000-06-01T00:00:00Z