Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
about
Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortalityDrug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric DisordersRepurposing drugs for the treatment and control of helminth infectionsLinked clinical trials--the development of new clinical learning studies in Parkinson's disease using screening of multiple prospective new treatmentsDrug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitorsDrug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisAssessing drug target association using semantic linked dataDrug Promiscuity in PDB: Protein Binding Site Similarity Is KeyGenerating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics DatabaseDistribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discoveryPrecompetitive preclinical ADME/Tox data: set it free on the web to facilitate computational model building and assist drug developmentDrug repositioning: a machine-learning approach through data integration.Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly.PDTD: a web-accessible protein database for drug target identification.Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2Drug repurposing and the medicinal chemist.High-content drug screening with engineered musculoskeletal tissuesFinding promiscuous old drugs for new uses.PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approachDrug repositioning through incomplete bi-cliques in an integrated drug-target-disease network.Target assessment for antiparasitic drug discovery.Virtual target screening: validation using kinase inhibitors.Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction.Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system.Structure-based systems biology for analyzing off-target bindingThe expanded biology of serotonin.Target validation: linking target and chemical properties to desired product profileAntagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment.Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.Drug Repurposing from an Academic Perspective.Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation.Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signalingAnti-tumoral effect of desmethylclomipramine in lung cancer stem cells.Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5SuperPred: drug classification and target prediction.In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling.Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery.Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses.The prince and the pauper. A tale of anticancer targeted agents.
P2860
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P2860
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
@ast
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
@en
type
label
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
@ast
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
@en
prefLabel
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
@ast
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
@en
P2860
P356
P1476
Finding new tricks for old drugs: an efficient route for public-sector drug discovery.
@en
P2093
Bryan L Roth
Kerry A O'Connor
P2860
P2888
P304
P356
10.1038/NRD1900
P577
2005-12-01T00:00:00Z