From knowing to controlling: a path from genomics to drugs using small molecule probes
about
Derivation of genetic interaction networks from quantitative phenotype dataAn Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and DisciplinesZINC--a free database of commercially available compounds for virtual screeningChemogenomics: an emerging strategy for rapid target and drug discoveryOncogenomics and the development of new cancer therapiesSmall molecules: the missing link in the central dogmaChemMine tools: an online service for analyzing and clustering small moleculesIdentification of New Molecular Entities (NMEs) as Potential Leads against Tuberculosis from Open Source Compound RepositoryTowards the optimal screening collection: a synthesis strategyGlobal mapping of pharmacological spaceAdvances in Nuclear Magnetic Resonance for Drug Discovery.A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators.A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model.Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.Finding new tricks for old drugs: an efficient route for public-sector drug discovery.Synthetic ligands able to interact with the p53 tetramerization domain. Towards understanding a protein surface recognition event.An antiproliferative genetic screening identifies a peptide aptamer that targets calcineurin and up-regulates its activity.Chemogenomics approaches to novel target discovery.Accelerated similarity searching and clustering of large compound sets by geometric embedding and locality sensitive hashing.Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity.Label-free detection of small-molecule-protein interactions by using nanowire nanosensors.Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons.Medicinal chemical properties of successful central nervous system drugsSynthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and β-amino alcohols.The Listeria monocytogenes σB regulon and its virulence-associated functions are inhibited by a small moleculeAccessing a small library of pluripotent 1,4,5-trisubstituted 1H-1,2,3-triazoles via diversity-oriented synthesis.Epigenetic approaches to psychiatric disorders.BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.Intramers and aptamers: applications in protein-function analyses and potential for drug screening.Discovery of histone deacetylase 8 selective inhibitors.In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions)Forward in reverse: how reverse genetics complements chemical genetics.Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.ChemBank: a small-molecule screening and cheminformatics resource databaseComputational systems chemical biology.Nanowire sensors for medicine and the life sciences.Identifying the proteins to which small-molecule probes and drugs bind in cells.Recent Applications of Imines as Key Intermediates in the Synthesis of Alkaloids and Novel Nitrogen Heterocycles.Two-headed PROTAC: an effective new tool for targeted protein degradation
P2860
Q21184166-1B072A57-BD15-4B33-964D-2620E7F49AB5Q26827563-116565F7-E557-4AD9-AE2B-2AD025B09D35Q27656255-E1E296F6-2A93-423D-BF9B-C44E2DE77428Q28260664-9A00D178-4C79-4423-85E4-44CA649BF07EQ28263634-D777D4A4-84F1-450E-952F-388605D3C727Q28291345-DEE61541-94EC-402F-AEF0-2C9F3665DEDAQ28530229-63AF7B51-DD28-46ED-A025-19EC6C8E38A0Q28551394-3C2110C9-7D9A-48D9-B369-9BA7AC5722A9Q28755381-B169BA1F-FF7F-4F84-9368-7D8D97962947Q29615876-3877AC89-C5A9-41B7-B9FE-5F58933674A8Q30387229-E0978D48-A017-436D-88B1-37DFEE43D708Q31029855-578F3B02-ADBC-4BD1-8E77-D18D83704EE2Q31155845-EA5DEED0-31D1-4D35-8A0D-00B698A7E2C9Q33224424-B56F8E46-E07B-43FB-BFF1-1B57225DA5BEQ33229063-9E8954E0-7701-45FA-8DB3-D6B30AEB3FA6Q33247742-DB419FA3-F1BE-4B3D-83A5-77E79C345304Q33265421-11538CAF-7AA7-41B3-A254-E601BA17A035Q33286936-00324523-8AEE-40E6-88DB-7CD969C9A8BDQ33533693-C1AE6CEF-EA4A-4D8A-9018-3876501BB350Q33839073-905BEC7A-2450-4E58-8E10-93D9F8413685Q33849527-4F5594EB-8488-4759-85E4-33AADE0CAE61Q33906867-D883C0DF-C7CC-4BF1-99BE-318E8B95F2C3Q33946968-19053E75-2CCE-4EF4-ACA2-F38E9C982515Q33964610-CE5555A5-73B9-45EC-998E-4CB2AF0032D4Q34020882-9BD93DC7-3B75-4CF4-A9EA-32F6E4CEB535Q34086530-7BE09849-8388-4B11-AD3D-6620232C6159Q34243170-26A083F7-2BE9-40A6-8330-3BA44EEAB540Q35237163-882CDFA7-ECBA-40F2-AAD2-7D0B4552B42AQ35254521-A69CBD31-4F05-4E3D-BFD7-96D48FA46D20Q36002329-2567FB0F-1182-4F32-965A-DA6550882855Q36111962-80F092B4-26E1-4D67-84B0-AD224C0E2498Q36176672-06FA9B3D-13FB-4436-A4BD-2005A7AA2E3CQ36186965-B00007BD-ADB3-4ED3-9D8D-E1D86D2FE507Q36316851-5AD3B27E-0839-4FA5-BF13-76A9772353B7Q36454111-FF2506EA-DA0E-499C-B163-132F9A21EF83Q36540581-058918F1-1AEB-4A59-AD20-155E09334D15Q36918083-8EDEF101-F62A-41B6-A236-F5CD199B3FB3Q37114227-FB66934F-DD40-439D-AC64-16446E3CDB2CQ37297115-6BE6F245-083D-44BC-A31D-F997D4F5C5C5Q37367308-547C43EA-18EE-444C-945A-BA5184355C96
P2860
From knowing to controlling: a path from genomics to drugs using small molecule probes
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
From knowing to controlling: a path from genomics to drugs using small molecule probes
@ast
From knowing to controlling: a path from genomics to drugs using small molecule probes
@en
From knowing to controlling: a path from genomics to drugs using small molecule probes
@nl
type
label
From knowing to controlling: a path from genomics to drugs using small molecule probes
@ast
From knowing to controlling: a path from genomics to drugs using small molecule probes
@en
From knowing to controlling: a path from genomics to drugs using small molecule probes
@nl
prefLabel
From knowing to controlling: a path from genomics to drugs using small molecule probes
@ast
From knowing to controlling: a path from genomics to drugs using small molecule probes
@en
From knowing to controlling: a path from genomics to drugs using small molecule probes
@nl
P356
P1433
P1476
From knowing to controlling: a path from genomics to drugs using small molecule probes
@en
P2093
Robert L Strausberg
Stuart L Schreiber
P356
10.1126/SCIENCE.1083395
P407
P577
2003-04-11T00:00:00Z