Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding
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Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signallinghSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damageNormal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphataseGenomic instability in cancer.DNA damage control: regulation and functions of checkpoint kinase 1Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Roles of Chk1 in cell biology and cancer therapyThe role of Cdc25A in the regulation of cell proliferation and apoptosisChk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpointTransforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A.Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domainCasein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradationMechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.CDC25A(Q110del): a novel cell division cycle 25A isoform aberrantly expressed in non-small cell lung cancerERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.siRNA-mediated downregulation of MMP-9 and uPAR in combination with radiation induces G2/M cell-cycle arrest in Medulloblastoma.Novel interactions between FOXM1 and CDC25A regulate the cell cycle.A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosisRegulation of the cellular DNA double-strand break response.Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines.Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuitCdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells.Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis.Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegansNew opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response.In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemiaZebrafish cdc25a is expressed during early development and limiting for post-blastoderm cell cycle progression.DNA damage checkpoints in mammals.GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.hSSB1 regulates both the stability and the transcriptional activity of p53
P2860
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P2860
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Chk1 kinase negatively regulat ...... phatase through 14-3-3 binding
@ast
Chk1 kinase negatively regulat ...... phatase through 14-3-3 binding
@en
Chk1 kinase negatively regulat ...... hatase through 14-3-3 binding.
@nl
type
label
Chk1 kinase negatively regulat ...... phatase through 14-3-3 binding
@ast
Chk1 kinase negatively regulat ...... phatase through 14-3-3 binding
@en
Chk1 kinase negatively regulat ...... hatase through 14-3-3 binding.
@nl
prefLabel
Chk1 kinase negatively regulat ...... phatase through 14-3-3 binding
@ast
Chk1 kinase negatively regulat ...... phatase through 14-3-3 binding
@en
Chk1 kinase negatively regulat ...... hatase through 14-3-3 binding.
@nl
P2093
P2860
P1476
Chk1 kinase negatively regulat ...... phatase through 14-3-3 binding
@en
P2093
Christine E Ryan
Helen Piwnica-Worms
Mei-Shya Chen
P2860
P304
P356
10.1128/MCB.23.21.7488-7497.2003
P407
P577
2003-11-01T00:00:00Z