Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. - Test2 - elhamkhani - TriplyDB

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.

http://www.wikidata.org/entity/Q33296879

about

Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses Genome-environment interactions that modulate aging: powerful targets for drug discovery Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity Genetics of healthy aging and longevity Genetic determinants of human health span and life span: progress and new opportunities Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures.Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old.Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol.Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation.HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.Disease variants in genomes of 44 centenarians.Computational biology for ageing.Genetic studies reveal the role of the endocrine and metabolic systems in aging.Analysis of nonlinear gene expression progression reveals extensive pathway and age-specific transitions in aging human brains Epigenetics decouples mutational from environmental robustness. Did it also facilitate multicellularity?Genome instability, cancer and aging.Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.Haemoglobin A(1c) and cognitive function in very old, cognitively intact men.Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups "Positive biology": the centenarian lesson C-reactive protein and familial risk for dementia: a phenotype for successful cognitive aging.Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.Genomics of human health and aging Inter-chromosomal level of genome organization and longevity-related phenotypes in humans The role of lipid-related genes, aging-related processes, and environment in healthspan Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children The genetic basis for survivorship in coronary artery disease.Variability in the immune system: of vaccine responses and immune states.Health-related phenotypes and longevity in danish twins Toward a systems biology framework for understanding aging and health span.Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans.Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.

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P2860

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.

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Aviv Bergman

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Gil Atzmon

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Kenny Ye

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Nir Barzilai

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P2860

Lipoprotein genotype and conserved pathway for exceptional longevity in humans

Waddington's canalization revisited: developmental stability and evolution.

Genetic pathways that regulate ageing in model organisms

Evolutionary capacitance as a general feature of complex gene networks

Transcriptional regulation of the human apolipoprotein genes

Unique lipoprotein phenotype and genotype associated with exceptional longevity

Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I

Hsp90 as a capacitor for morphological evolution

Hsp90 as a capacitor of phenotypic variation

Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity

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