GSK-3beta controls osteogenesis through regulating Runx2 activity.
about
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progressionTrypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leadsLef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific mannerConditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation.Novel links among Wnt and TGF-beta signaling and Runx2.Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiationBMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activityHigh throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage.O-GlcNAc modification of the runt-related transcription factor 2 (Runx2) links osteogenesis and nutrient metabolism in bone marrow mesenchymal stem cells.β-Catenin independent cross-control between the estradiol and Wnt pathways in osteoblastsFibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway.Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agentsA Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Frontal Bone Insufficiency in Gsk3β Mutant Mice.Update on Wnt signaling in bone cell biology and bone disease.A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation.Wnt signaling in bone development and disease: making stronger bone with WntsTranscriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient miceWnt signaling in bone formation and its therapeutic potential for bone diseases.A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells.Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cellsWnt signaling behaves as a "master regulator" in the osteogenic and adipogenic commitment of human amniotic fluid mesenchymal stem cells.GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life spanIdentification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.Targeting the Wnt signaling pathway to augment bone formation.Post-translational Regulation of Runx2 in Bone and Cartilage.Environmental Factors Impacting Bone-Relevant Chemokines.Identification of Elongated Primary Cilia with Impaired Mechanotransduction in Idiopathic Scoliosis Patients.Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells.Wnt and the Wnt signaling pathway in bone development and disease.Control of osteogenesis by the canonical Wnt and BMP pathways in vivo: cooperation and antagonism between the canonical Wnt and BMP pathways as cells differentiate from osteochondroprogenitors to osteoblasts and osteocytes.Emerging therapeutic targets for osteoporosis treatment.Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats.Bone Cell Bioenergetics and Skeletal Energy Homeostasis.Covalent Modifications of RUNX Proteins: Structure Affects Function.
P2860
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P2860
GSK-3beta controls osteogenesis through regulating Runx2 activity.
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
GSK-3beta controls osteogenesis through regulating Runx2 activity.
@ast
GSK-3beta controls osteogenesis through regulating Runx2 activity.
@en
type
label
GSK-3beta controls osteogenesis through regulating Runx2 activity.
@ast
GSK-3beta controls osteogenesis through regulating Runx2 activity.
@en
prefLabel
GSK-3beta controls osteogenesis through regulating Runx2 activity.
@ast
GSK-3beta controls osteogenesis through regulating Runx2 activity.
@en
P2093
P2860
P1433
P1476
GSK-3beta controls osteogenesis through regulating Runx2 activity.
@en
P2093
Fumitaka Kugimiya
Hiroshi Kawaguchi
Hirotaka Chikuda
Kozo Nakamura
Makoto Hirata
Naohiro Kawamura
Shinsuke Ohba
Ung-il Chung
Yoshiaki Azuma
P2860
P356
10.1371/JOURNAL.PONE.0000837
P407
P577
2007-09-05T00:00:00Z