Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
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Shifting from the single to the multitarget paradigm in drug discoveryHigh-throughput analysis of behavior for drug discoveryParallel Synthesis of an Imidazole-4,5-dicarboxamide Library Bearing Amino Acid Esters and AlkanaminesInsights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental studyComprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking LibraryFlow Cytometry: Impact on Early Drug DiscoveryLarge-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure.Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches.Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.From rapid in vitro screening to rapid in vivo screening in the drug discovery process.Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.New strategies for the design of folded peptoids revealed by a survey of noncovalent interactions in model systemsIdentification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial librarySAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs).Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries.Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.Estimation of affinities of ligands in mixtures via magnetic recovery of target-ligand complexes and chromatographic analyses: chemometrics and an experimental model.Composition and applications of focus libraries to phenotypic assaysInhibitor screening of proprotein convertases using positional scanning libraries.Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes.Molecular scaffold analysis of natural products databases in the public domain.A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning librariesDiscovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptorsSelective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities.Balancing novelty with confined chemical space in modern drug discovery.Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin.Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT)Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents.
P2860
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P2860
Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Strategies for the use of mixt ...... tion by computational methods.
@ast
Strategies for the use of mixt ...... tion by computational methods.
@en
Strategies for the use of mixt ...... tion by computational methods.
@nl
type
label
Strategies for the use of mixt ...... tion by computational methods.
@ast
Strategies for the use of mixt ...... tion by computational methods.
@en
Strategies for the use of mixt ...... tion by computational methods.
@nl
prefLabel
Strategies for the use of mixt ...... tion by computational methods.
@ast
Strategies for the use of mixt ...... tion by computational methods.
@en
Strategies for the use of mixt ...... tion by computational methods.
@nl
P2093
P356
P1476
Strategies for the use of mixt ...... tion by computational methods.
@en
P2093
Adel Nefzi
Clemencia Pinilla
Colette T Dooley
Daniela Brunner
Gerald M Maggiora
Jeff Schneider
John M Ostresh
Jon R Appel
Jose L Medina-Franco
Marc A Giulianotti
P356
10.1021/CC7001205
P577
2007-12-08T00:00:00Z