Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
about
The ubiquitin proteasome system in neuropathologyStructural Basis of E2-25K/UBB+1 Interaction Leading to Proteasome Inhibition and NeurotoxicityUbiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implicationsSTUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity.Defining the limits: Protein aggregation and toxicity in vivoMutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment.Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogasterAccumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant UbiquitinThe 26S Proteasome Degrades the Soluble but Not the Fibrillar Form of the Yeast Prion Ure2p In Vitro.Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis.The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.Sequestration of essential proteins causes prion associated toxicity in yeast.Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence.Cell cycle deregulation in the neurons of Alzheimer's disease.Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.Role of frameshift ubiquitin B protein in Alzheimer's disease.Mutant ubiquitin attenuates interleukin-1β- and tumor necrosis factor-α-induced pro-inflammatory signaling in human astrocytic cells.Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.A role for the proteasome in the turnover of Sup35p and in [PSI(+) ] prion propagation.Ubiquitylation at the crossroads of development and disease.Detrimental effects of proteasome inhibition activity in Drosophila melanogaster: implication of ER stress, autophagy, and apoptosis.Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts.Linear ubiquitin chain induces apoptosis and inhibits tumor growth.Dysfunction of Protein Quality Control in Parkinsonism-Dementia Complex of Guam.Different Expression Levels of Human Mutant Ubiquitin B+1 (UBB+1) Can Modify Chronological Lifespan or Stress Resistance of Saccharomyces cerevisiae.Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
P2860
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P2860
Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Disease-associated mutant ubiq ...... oxicity of protein aggregates.
@ast
Disease-associated mutant ubiq ...... oxicity of protein aggregates.
@en
type
label
Disease-associated mutant ubiq ...... oxicity of protein aggregates.
@ast
Disease-associated mutant ubiq ...... oxicity of protein aggregates.
@en
prefLabel
Disease-associated mutant ubiq ...... oxicity of protein aggregates.
@ast
Disease-associated mutant ubiq ...... oxicity of protein aggregates.
@en
P2860
P1433
P1476
Disease-associated mutant ubiq ...... oxicity of protein aggregates.
@en
P2093
Elizabeth M H Tank
Heather L True
P2860
P304
P356
10.1371/JOURNAL.PGEN.1000382
P577
2009-02-13T00:00:00Z