Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. - Test2 - elhamkhani - TriplyDB

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.

http://www.wikidata.org/entity/Q33494281

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers Targeting the Pim kinases in multiple myeloma Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor Targeting Pim kinases for cancer treatment: opportunities and challenges The PIM kinases in hematological cancers PIM1 kinase as a target for cancer therapy Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia In vitro gene regulatory networks predict in vivo function of liver High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1.The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication Expression of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa co-determines the prognosis of colon cancer patients.The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program.PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.Using quantitative real-time PCR to determine donor cell engraftment in a competitive murine bone marrow transplantation model.Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.Identification of quinones as novel PIM1 kinase inhibitors Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value.Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells PIM kinases as therapeutic targets against advanced melanoma.Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into β-arrestin-dependent ERK signaling.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.Role of CXCR4 in the pathogenesis of acute myeloid leukemia.The PIM family of serine/threonine kinases in cancer.Targeting Pim1 kinase in the treatment of peanut allergy.

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P2860

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.

http://www.wikidata.org/entity/Q33494281

description

2009 nî lūn-bûn

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2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年論文

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Dissection of PIM serine/threo ...... mediated homing and migration.

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Dissection of PIM serine/threo ...... mediated homing and migration.

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Dissection of PIM serine/threo ...... mediated homing and migration.

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Dissection of PIM serine/threo ...... mediated homing and migration.

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Dissection of PIM serine/threo ...... mediated homing and migration.

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Dissection of PIM serine/threo ...... mediated homing and migration.

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Dissection of PIM serine/threo ...... mediated homing and migration.

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Alex N Bullock

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Andrea Biondi

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Anke Spoo

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Antonello Villa

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Christelle Gasser

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Christine Dierks

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Georgina Berridge

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Juerg Schwaller

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Justus Duyster

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Laurent Brault

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P2860

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism.

Structure and substrate specificity of the Pim-1 kinase.

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.

Chemokine receptor trafficking and viral replication.

Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.

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10.1084/JEM.20082074

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