Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.
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Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese populationAMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndromeLeukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signalingWHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4Ibrutinib in Waldenström macroglobulinemia: latest evidence and clinical experienceDipeptidyl Peptidase-4 Regulation of SDF-1/CXCR4 Axis: Implications for Cardiovascular DiseaseDiversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular PerspectivesHuman Immunodeficiencies Related to Defective APC/T Cell InteractionG-CSF and GM-CSF in NeutropeniaPrimary immunodeficiency update: Part II. Syndromes associated with mucocutaneous candidiasis and noninfectious cutaneous manifestationsCongenital defects in neutrophil dynamicsHIV: cell binding and entryImmature B Cell Egress from Bone Marrow Is SOCS3 IndependentRare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traitsApigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expressionImpaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptorNovel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control studyLive imaging of neutrophil motility in a zebrafish model of WHIM syndromeThe CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapseNeutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrowCXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathwaysCXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrowSmall neutralizing molecules to inhibit actions of the chemokine CXCL12.Congenital neutropenia: diagnosis, molecular bases and patient management.Autoimmune and other cytopenias in primary immunodeficiencies: pathomechanisms, novel differential diagnoses, and treatmentDissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors.Familial occurrence of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndromePotential large animal models for gene therapy of human genetic diseases of immune and blood cell systemsCXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulationAn essential role of the cytoplasmic tail of CXCR4 in G-protein signaling and organogenesis.Emerging concepts and approaches for chemokine-receptor drug discovery.Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time.Oligoclonality, impaired class switch and B-cell memory responses in WHIM syndromeA novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transferChaperoning G protein-coupled receptors: from cell biology to therapeuticsCXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrowChemokine signaling in cancer: Implications on the tumor microenvironment and therapeutic targeting
P2860
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P2860
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@ast
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@en
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@nl
type
label
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@ast
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@en
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@nl
altLabel
Mutations in the chemokine rec ...... bined immunodeficiency disease
@en
prefLabel
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@ast
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@en
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@nl
P2093
P356
P1433
P1476
Mutations in the chemokine rec ...... ined immunodeficiency disease.
@en
P2093
Fleur Francois
George A Diaz
John N Lukens
Joze Bohinjec
Mary E Klotman
Paolo A Hernandez
Robert J Gorlin
Shoichiro Taniuchi
P2888
P356
10.1038/NG1149
P407
P577
2003-05-01T00:00:00Z