about
Two-pore channels form homo- and heterodimersInternational Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyThe role of TRPMLs in endolysosomal trafficking and functionA TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their ExpulsionRegulation of lysosomal ion homeostasis by channels and transportersTPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomesConstitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small moleculesGenetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in miceHeteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagyZinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel.Lysosomal physiology.A novel ion channel formed by interaction of TRPML3 with TRPV5.Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1.Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins.Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channelsIdentification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.Regulation of TRPML1 function.Organellar channels and transporters.Phosphoinositide isoforms determine compartment-specific ion channel activityRole of TRP channels in the regulation of the endosomal pathway.The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.Inside job: ligand-receptor pharmacology beneath the plasma membrane.Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRLThe role of transient receptor potential cation channels in Ca2+ signalingPairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes.A New Perspective of Lysosomal Cation Channel-Dependent Homeostasis in Alzheimer's Disease.Calcium signaling in membrane repair.Inhibition of Transient Receptor Potential Channel Mucolipin-1 (TRPML1) by Lysosomal Adenosine Involved in Severe Combined Immunodeficiency Diseases.ROS and intracellular ion channels.Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene.The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling.Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx.Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.Opening the TRPML gates.A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium releaseDeviant lysosomal Ca2+ signalling in neurodegeneration. An introduction.Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Small molecule activators of TRPML3
@ast
Small molecule activators of TRPML3
@en
Small molecule activators of TRPML3.
@nl
type
label
Small molecule activators of TRPML3
@ast
Small molecule activators of TRPML3
@en
Small molecule activators of TRPML3.
@nl
prefLabel
Small molecule activators of TRPML3
@ast
Small molecule activators of TRPML3
@en
Small molecule activators of TRPML3.
@nl
P2093
P2860
P1476
Small molecule activators of TRPML3
@en
P2093
Bifeng Pan
Christian Grimm
Kazuo Oshima
Peter Chase
Peter Hodder
S Adrian Saldanha
Simone Jörs
Stefan Heller
P2860
P304
P356
10.1016/J.CHEMBIOL.2009.12.016
P577
2010-02-01T00:00:00Z