Small molecule activators of TRPML3 - Test2 - elhamkhani - TriplyDB

Small molecule activators of TRPML3

Small molecule activators of TRPML3

http://www.wikidata.org/entity/Q33535026

about

Two-pore channels form homo- and heterodimers International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family The role of TRPMLs in endolysosomal trafficking and function A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion Regulation of lysosomal ion homeostasis by channels and transporters TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel.Lysosomal physiology.A novel ion channel formed by interaction of TRPML3 with TRPV5.Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1.Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins.Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.Regulation of TRPML1 function.Organellar channels and transporters.Phosphoinositide isoforms determine compartment-specific ion channel activity Role of TRP channels in the regulation of the endosomal pathway.The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.Inside job: ligand-receptor pharmacology beneath the plasma membrane.Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL The role of transient receptor potential cation channels in Ca2+ signaling Pairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes.A New Perspective of Lysosomal Cation Channel-Dependent Homeostasis in Alzheimer's Disease.Calcium signaling in membrane repair.Inhibition of Transient Receptor Potential Channel Mucolipin-1 (TRPML1) by Lysosomal Adenosine Involved in Severe Combined Immunodeficiency Diseases.ROS and intracellular ion channels.Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene.The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling.Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx.Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.Opening the TRPML gates.A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release Deviant lysosomal Ca2+ signalling in neurodegeneration. An introduction.Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.

P2860

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P2860

Small molecule activators of TRPML3

http://www.wikidata.org/entity/Q33535026

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Small molecule activators of TRPML3

@ast

Small molecule activators of TRPML3

@en

Small molecule activators of TRPML3.

@nl

type

label

Small molecule activators of TRPML3

@ast

Small molecule activators of TRPML3

@en

Small molecule activators of TRPML3.

@nl

prefLabel

Small molecule activators of TRPML3

@ast

Small molecule activators of TRPML3

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Small molecule activators of TRPML3.

@nl

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J.CHEMBIOL.2009.12.016

P1433

Chemistry and Biology

P1476

Small molecule activators of TRPML3

@en

P2093

Bifeng Pan

http://www.w3.org/2001/XMLSchema#string

Christian Grimm

http://www.w3.org/2001/XMLSchema#string

Kazuo Oshima

http://www.w3.org/2001/XMLSchema#string

Peter Chase

http://www.w3.org/2001/XMLSchema#string

Peter Hodder

http://www.w3.org/2001/XMLSchema#string

S Adrian Saldanha

http://www.w3.org/2001/XMLSchema#string

Simone Jörs

http://www.w3.org/2001/XMLSchema#string

Stefan Heller

http://www.w3.org/2001/XMLSchema#string

P2860

Subunit composition of mammalian transient receptor potential channels in living cells

Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype

Life and death of sensory hair cells expressing constitutively active TRPML3

The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4

An introduction to TRP channels

Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1

The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy

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135-148

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scholarly article

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10.1016/J.CHEMBIOL.2009.12.016

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P433

2

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P478

17

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P50

Alexander G. Obukhov

Math P. Cuajungco

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2010-02-01T00:00:00Z

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41621688

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20189104

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2834294

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