Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.
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The molecular mechanism of eukaryotic elongation factor 2 kinase activationCalcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cellsMetabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor libraryTargeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancerPrimary trastuzumab resistance: new tricks for an old drug.Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2KThree 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC.eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expressionNAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response.Staying alive: metabolic adaptations to quiescenceInhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways.Loss of autophagy-related protein Beclin 1 may define poor prognosis in ovarian clear cell carcinomasDepletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes.Autophagic pathways as new targets for cancer drug development.Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment.The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancerTherapeutic targeting of autophagy in disease: biology and pharmacology.Targeting autophagic pathways for cancer drug discoverymTORC1 signaling: what we still don't know.Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation.The effect of selenium enrichment on baker's yeast proteomeSilencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma.Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells.Eukaryotic elongation factor-2 kinase (eEF2K): a potential therapeutic target in cancer.Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme's stability under stress conditions.MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis.Everolimus enhances cellular cytotoxicity of lapatinib via the eukaryotic elongation factor-2 kinase pathway in nasopharyngeal carcinoma cells.Autophagy, a novel pathway to regulate calcium mobilization in T lymphocytes.Reversible covalent inhibition of eEF-2K by carbonitriles.Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of Raddeanin A against human breast cancer cells in vitro.eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis.Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma
P2860
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P2860
Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.
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2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Cytoprotective effect of the e ...... d to growth factor inhibition.
@ast
Cytoprotective effect of the e ...... d to growth factor inhibition.
@en
Cytoprotective effect of the e ...... d to growth factor inhibition.
@nl
type
label
Cytoprotective effect of the e ...... d to growth factor inhibition.
@ast
Cytoprotective effect of the e ...... d to growth factor inhibition.
@en
Cytoprotective effect of the e ...... d to growth factor inhibition.
@nl
prefLabel
Cytoprotective effect of the e ...... d to growth factor inhibition.
@ast
Cytoprotective effect of the e ...... d to growth factor inhibition.
@en
Cytoprotective effect of the e ...... d to growth factor inhibition.
@nl
P2093
P2860
P1433
P1476
Cytoprotective effect of the e ...... d to growth factor inhibition.
@en
P2093
Huaijun Li
Jinming Yang
Tingkuang Niu
William N Hait
Xingcong Ren
P2860
P356
10.1371/JOURNAL.PONE.0009715
P407
P577
2010-03-16T00:00:00Z