A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin
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Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neuronscdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent mannerDistinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cellsMechanotransduction in skeletal muscleEukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseasesMolecular Connections between Cancer Cell Metabolism and the Tumor MicroenvironmentStimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stressesThe molecular mechanism of eukaryotic elongation factor 2 kinase activationCalcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependenceInterleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with CalmodulinImpaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscleAn RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon.Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones.Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in DrosophilaSirolimus therapy following early cyclosporine withdrawal in transplant patients: mechanisms of action and clinical results.Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.Fetal and neonatal programming of postnatal growth and feed efficiency in swine.Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis.Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.New frontiers in translational control of the cancer genomeAcute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2).Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.Nutrient signalling in the regulation of human muscle protein synthesis.Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signalingmTORC1 dependent regulation of REDD1 protein stability.Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cellsmTORC1-mediated translational elongation limits intestinal tumour initiation and growth.Frontier of epilepsy research - mTOR signaling pathway.The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.Targeting the phosphatidylinositol 3-kinase signaling pathway in breast cancer.Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains.The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells.
P2860
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P2860
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin
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2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@ast
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@en
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@nl
type
label
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@ast
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@en
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@nl
prefLabel
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@ast
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@en
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@nl
P2860
P3181
P1476
A novel mTOR-regulated phospho ...... and its binding to calmodulin
@en
P2093
Gareth J Browne
P2860
P304
P3181
P356
10.1128/MCB.24.7.2986-2997.2004
P407
P577
2004-04-01T00:00:00Z