Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. - Test2 - elhamkhani - TriplyDB

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.

http://www.wikidata.org/entity/Q33553429

about

Insulin in the brain: there and back again Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier Roles of low-density lipoprotein receptor-related protein 1 in tumors LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.Neuronal clearance of amyloid-β by endocytic receptor LRP1.Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction.Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice Sorting nexin 17 regulates ApoER2 recycling and reelin signaling The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury.α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death.Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration.LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Mesenchymal Stromal Cells Promote Axonal Outgrowth Alone and Synergistically with Astrocytes via tPA Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment A sorting nexin 17-binding domain within the LRP1 cytoplasmic tail mediates receptor recycling through the basolateral sorting endosome.Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration.Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons.LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury.Dissecting the association between migraine and stroke.Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies.Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions.Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis.Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan.Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation.The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains.LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease.Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells.MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease.Blockade of extracellular heat shock protein 90α by 1G6-D7 attenuates pulmonary fibrosis through inhibiting ERK signaling.LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair.Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzheimer's disease transgenic mouse model.Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.

P2860

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P2860

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.

http://www.wikidata.org/entity/Q33553429

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Low density lipoprotein recept ...... tivating Akt survival pathway.

@ast

Low density lipoprotein recept ...... tivating Akt survival pathway.

@en

Low density lipoprotein recept ...... tivating Akt survival pathway.

@nl

type

label

Low density lipoprotein recept ...... tivating Akt survival pathway.

@ast

Low density lipoprotein recept ...... tivating Akt survival pathway.

@en

Low density lipoprotein recept ...... tivating Akt survival pathway.

@nl

prefLabel

Low density lipoprotein recept ...... tivating Akt survival pathway.

@ast

Low density lipoprotein recept ...... tivating Akt survival pathway.

@en

Low density lipoprotein recept ...... tivating Akt survival pathway.

@nl

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JBC.M109.021030

P1433

Journal of Biological Chemistry

P1476

Low density lipoprotein recept ...... tivating Akt survival pathway.

@en

P2093

Guojun Bu

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Juan Zhang

http://www.w3.org/2001/XMLSchema#string

Qiang Liu

http://www.w3.org/2001/XMLSchema#string

Takahisa Kanekiyo

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P2860

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity

Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae

Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae

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34045-34053

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10.1074/JBC.M109.021030

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49

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P478

284

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Rodrigo A Fuentealba

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2009-10-08T00:00:00Z

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19815552

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P921

apoptotic process

P932

2797175

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