Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria. - Test2 - elhamkhani - TriplyDB

Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.

Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.

http://www.wikidata.org/entity/Q33556308

about

A small mitochondrial protein present in myzozoans is essential for malaria transmission.Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation.Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase A novel 'gene insertion/marker out' (GIMO) method for transgene expression and gene complementation in rodent malaria parasites Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria?Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins Distinct properties of the egress-related osmiophilic bodies in male and female gametocytes of the rodent malaria parasite Plasmodium berghei The novel putative transporter NPT1 plays a critical role in early stages of Plasmodium berghei sexual development Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole Distinct placental malaria pathology caused by different Plasmodium berghei lines that fail to induce cerebral malaria in the C57BL/6 mouse.Imaging Plasmodium immunobiology in the liver, brain, and lung.A unique profilin-actin interface is important for malaria parasite motility Protection from experimental cerebral malaria with a single dose of radiation-attenuated, blood-stage Plasmodium berghei parasites.Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito Protease-associated cellular networks in malaria parasite Plasmodium falciparum.Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance.Imperfect duplicate insertions type of mutations in plasmepsin V modulates binding properties of PEXEL motifs of export proteins in Indian Plasmodium vivax.Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host.Noninvasive biophotonic imaging for studies of infectious disease.Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite Characterization and tissue-specific expression patterns of the Plasmodium chabaudi cir multigene family.Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype.Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo.Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity.Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria.Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches.Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to Heating The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment.An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycle Murine Model for Preclinical Studies of Var2CSA-Mediated Pathology Associated with Malaria in Pregnancy Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites.Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasites Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors.Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro.Protective immunity against malaria after vaccination.

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Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.

http://www.wikidata.org/entity/Q33556308

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2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Plasmepsin 4-deficient Plasmod ...... against experimental malaria.

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Plasmepsin 4-deficient Plasmod ...... against experimental malaria.

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AJPATH.2010.090504

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The American Journal of Pathology

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Plasmepsin 4-deficient Plasmod ...... against experimental malaria.

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Andrea Savarino

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Andrew P Waters

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Antonio Cassone

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Francesco Bistoni

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J Alfredo Bonilla

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John B Dame

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Luke M Syphard

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Roberta Spaccapelo

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Sara Caterbi

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Tania Dottorini

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P2860

A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.

High efficiency transfection of Plasmodium berghei facilitates novel selection procedures

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration.

A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria.

Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans.

Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man.

Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface

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205-217

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1

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176

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Andrea Crisanti

Manlio Di Cristina

Blandine Franke-Fayard

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2009-12-17T00:00:00Z

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40696556

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20019192

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Plasmodium berghei

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2797883

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