Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets. - Test2 - elhamkhani - TriplyDB

Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets.

Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets.

http://www.wikidata.org/entity/Q33566479

about

Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy A systems level, functional genomics analysis of chronic epilepsy mTOR and MAPK: from localized translation control to epilepsy Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1 A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element.The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons.siRNA off-target effects can be reduced at concentrations that match their individual potency Signatures of RNA binding proteins globally coupled to effective microRNA target sites HuD regulates coding and noncoding RNA to induce APP→Aβ processing.Regulation of protein levels in subcellular domains through mRNA transport and localized translation.miR-375 inhibits differentiation of neurites by lowering HuD levels.HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA.Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits.HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites.Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice.Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD.A post-transcriptional mechanism pacing expression of neural genes with precursor cell differentiation status.Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1.Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis Widespread splicing changes in human brain development and aging.Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines.Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain.Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons.Axonally synthesized β-actin and GAP-43 proteins support distinct modes of axonal growth.Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons.Neuroserpin up-regulation in the Alzheimer's disease brain is associated with elevated thyroid hormone receptor-β1 and HuD expression.Molecular determinants of the axonal mRNA transcriptome.Subcellular communication through RNA transport and localized protein synthesis The complex world of post-transcriptional mechanisms: is their deregulation a common link for diseases? Focus on ELAV-like RNA-binding proteins.Trans-acting factors governing acetylcholinesterase mRNA metabolism in neurons.Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction Postnatal dynamics of Zeb2 expression in rat brain: analysis of novel 3' UTR sequence reveals a miR-9 interacting site.ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism.Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?A majority of the cancer/testis antigens are intrinsically disordered proteins mTOR referees memory and disease through mRNA repression and competition.Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease.Perspectives on the ARE as it turns 25 years old.

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Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets.

http://www.wikidata.org/entity/Q33566479

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Novel recognition motifs and b ...... identification of its targets.

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Federico Bolognani

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Nora I Perrone-Bizzozero

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Tania Contente-Cuomo

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P2860

HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal

CUG-BP binds to RNA substrates and recruits PARN deadenylase

Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1

Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1

MEME: discovering and analyzing DNA and protein sequence motifs

CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding

The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies

WebGestalt: an integrated system for exploring gene sets in various biological contexts.

ARED 3.0: the large and diverse AU-rich transcriptome.

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10.1093/NAR/GKP863

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1

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38

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