Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.
about
Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitorsMulti-Facial, Non-Peptidic α-Helix MimeticsAdding diverse noncanonical backbones to rosetta: enabling peptidomimetic designOxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic speciesStructure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Å resolutionA spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell cultureEnhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein InteractionsA Strategy for Direct Chemical Activation of the Retinoblastoma ProteinNMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexesIn vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding.Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsPotential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines.Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.Targeting protein-protein interactions as an anticancer strategyA screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsDesign of libraries targeting protein-protein interfaces.Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactionsStructure-guided optimization of small molecule c-Abl activatorsResolving hot spots in the C-terminal dimerization domain that determine the stability of the molecular chaperone Hsp90Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions.A re-examination of the MDM2/p53 interaction leads to revised design criteria for novel inhibitors.Assessing helical protein interfaces for inhibitor design.An orthosteric inhibitor of the Ras-Sos interaction.Synthesis of atropisomerically defined, highly substituted biaryl scaffolds through catalytic enantioselective bromination and regioselective cross-couplingTowards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helicesDARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review.Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.Cationic acyclic cucurbit[n]uril-type containers: synthesis and molecular recognition toward nucleotides.Helix-mediated protein--protein interactions as targets for intervention using foldamers.Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein interactions.Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimeticsRelaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.Folded small molecule manipulation of islet amyloid polypeptide.
P2860
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P2860
Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@ast
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@en
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@nl
type
label
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@ast
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@en
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@nl
prefLabel
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@ast
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@en
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@nl
P1476
Disrupting protein-protein int ...... molecule alpha-helix mimetics.
@en
P2093
Andrew D Hamilton
Christopher G Cummings
P304
P356
10.1016/J.CBPA.2010.04.001
P577
2010-04-27T00:00:00Z