Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. - Test2 - elhamkhani - TriplyDB

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

http://www.wikidata.org/entity/Q37011508

about

Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks Protein lysine acetylation by p300/CBP Ordering a Dynamic Protein Via a Small-Molecule Stabilizer A natural-product switch for a dynamic protein interface The role of HTS in drug discovery at the University of Michigan.Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Prepaying the entropic cost for allosteric regulation in KIX Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription.Fragment screening and druggability assessment for the CBP/p300 KIX domain through protein-observed 19F NMR spectroscopy.Targeting transcription is no longer a quixotic quest Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein-protein interaction From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.Targeting Unoccupied Surfaces on Protein-Protein Interfaces.Tuning Sulfur Oxidation States on Thioether-Bridged Peptide Macrocycles for Modulation of Protein Interactions.A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly.A Natural-Product Switch for a Dynamic Protein Interface

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Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

http://www.wikidata.org/entity/Q37011508

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 October 2012

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

@en

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

@nl

type

label

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

@en

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

@nl

prefLabel

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

@en

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

@nl

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Angewandte Chemie International Edition

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Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

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Anna K Mapp

http://www.w3.org/2001/XMLSchema#string

Carl J Arevang

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Charles L Brooks

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Chinmay Y Majmudar

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Conor H Doss

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David H Sherman

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Jessica K Gagnon

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Laura C Cesa

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Pamela J Schultz

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Steven P Rowe

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P2860

Intrinsically unstructured proteins and their functions

Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain

Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

Fine-tuning multiprotein complexes using small molecules

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

A transcriptional activating region with two contrasting modes of protein interaction.

CBP/p300 in cell growth, transformation, and development

Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain

Transcriptional activation by recruitment

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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11258-11262

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scholarly article

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10.1002/ANIE.201206815

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45

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51

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Giselle Tamayo-Castillo

Jonas W. Højfeldt

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2012-10-08T00:00:00Z

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232066433

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23042634

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